{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:07:15Z","timestamp":1777730835350,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T00:00:00Z","timestamp":1314057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Yersinia pestis, a Gram-negative bacillus causing plague and Centers for Disease Control and Prevention (CDC) classified Category A pathogen, has high potential as a bioweapon. Lipopolysaccharide, a virulence factor for Y. pestis, binds to and activates A\n                    <jats:sub>1<\/jats:sub>\n                    adenosine receptor (AR)s and, in animals, A\n                    <jats:sub>1<\/jats:sub>\n                    AR antagonists block induced acute lung injury (ALI) and increase survival following cecal ligation and perforation. In this study, rats were infected intratracheally with viable Y. pestis [CO99 (pCD1\n                    <jats:sup>+<\/jats:sup>\n                    \/\u0394pgm) 1 \u00d7 10\n                    <jats:sup>8<\/jats:sup>\n                    CFU\/animal] and treated daily for 3 d with ciprofloxacin (cipro), the A\n                    <jats:sub>1<\/jats:sub>\n                    AR antagonist L-97-1, or cipro plus L-97-1 starting at 0, 6, 24, 48, or 72\u2009h post- Y. pestis. At 72\u2009h post- Y. pestis, cipro plus L-97-1 significantly improved 6-d survival to 60\u201370% vs 28% for cipro plus H\n                    <jats:sub>2<\/jats:sub>\n                    O and 33% for untreated Y. pestis controls ( P\u2009=\u20090.02, logrank test). Lung edema, hemorrhage and leukocyte infiltration index (LII) were evaluated histologically to produce ALI scores. Cipro plus L-97-1 significantly reduced lung edema, as well as aggregate lung injury scores vs controls or cipro plus H\n                    <jats:sub>2<\/jats:sub>\n                    O, and LII vs controls ( P\u2009&lt;\u20090.05, Student\u2019s unpaired t test). These results support efficacy for L-97-1 as a post-exposure medical countermeasure, adjunctive therapy to antibiotics for Y. pestis.\n                  <\/jats:p>","DOI":"10.1177\/1753425911411595","type":"journal-article","created":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T22:26:10Z","timestamp":1314138370000},"page":"373-389","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["A novel post-exposure medical countermeasure L-97-1 improves survival and acute lung injury following intratracheal infection with\n                    <i>Yersinia pestis<\/i>"],"prefix":"10.1177","volume":"18","author":[{"given":"Constance N","family":"Wilson","sequence":"first","affiliation":[{"name":"Endacea Inc., Research Triangle Park, NC, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance O","family":"Vance","sequence":"additional","affiliation":[{"name":"Endacea Inc., Research Triangle Park, NC, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M","family":"Doyle","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, St. Louis, MO, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S","family":"Brink","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, St. Louis, MO, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M","family":"Matuschak","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, St. Louis, MO, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J","family":"Lechner","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, St. Louis, MO, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,8,23]]},"reference":[{"key":"bibr1-1753425911411595","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.35"},{"key":"bibr2-1753425911411595","unstructured":"World Health Organization. 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