{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:18:25Z","timestamp":1791962305327,"version":"4.3.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    Deficiency of mannose-binding lectin (MBL), a serum protein involved in killing and promoting phagocytosis of pathogens, is associated with respiratory infection and disease progression in a number of acute and chronic lung diseases, including cystic fibrosis (CF)- associated bronchiectasis. No such association has been studied in non-CF bronchiectasis (nCF-Br). One hundred and thirty-three adult patients with nCF-Br were studied. Serum MBL levels were measured and deficiency defined using two cut-off levels, i.e. MBL \u2264100\u2009ng\/ml and \u2264600\u2009ng\/ml. Parameters of severity included lung function impairment, annual exacerbation and hospital admission rates, breathlessness, and Pseudomonas aeruginosa and Haemophilus influenzae infection rates. The incidence of MBL deficiency using cut-off levels of 100\u2009ng\/ml and 600\u2009ng\/ml was 10% and 26% respectively, similar to rates seen in the general population. There was no significant difference in mean FEV\n                    <jats:sub>1<\/jats:sub>\n                    % predicted between MBL deficient and sufficient patients at both cut-off levels (\u2264100\u2009ng\/ml: 63.8% vs . 64.6%, P\u2009=\u20090.91;\u2009\u2264\u2009600\u2009ng\/ml: 66.5% vs . 63.9%, P\u2009=\u20090.56). In addition, exacerbation\/hospital admission rates, symptoms of breathlessness and isolation\/colonisation rates with P. aeruginosa and H. influenzae were similar in both groups at both cut-off levels. In conclusion, MBL deficiency is not associated with markers of disease severity in patients with nCF-Br.\n                  <\/jats:p>","DOI":"10.1177\/1753425912440472","type":"journal-article","created":{"date-parts":[[2012,3,3]],"date-time":"2012-03-03T04:15:45Z","timestamp":1330748145000},"page":"787-792","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Low serum mannose-binding lectin level is not associated with disease severity in non-cystic fibrosis bronchiectasis"],"prefix":"10.1177","volume":"18","author":[{"given":"James G","family":"Macfarlane","sequence":"first","affiliation":[{"name":"Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Jary","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine LM","family":"Hester","sequence":"additional","affiliation":[{"name":"Sir William Leech Centre for Respiratory Research, Freeman Hospital, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"McAlinden","sequence":"additional","affiliation":[{"name":"Sir William Leech Centre for Respiratory Research, Freeman Hospital, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wake","sequence":"additional","affiliation":[{"name":"Regional Immunology Service, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese","family":"Small","sequence":"additional","affiliation":[{"name":"Sir William Leech Centre for Respiratory Research, Freeman Hospital, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy E","family":"Walton","sequence":"additional","affiliation":[{"name":"Microbiology Department, Freeman Hospital, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Spickett","sequence":"additional","affiliation":[{"name":"Regional Immunology Service, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"De Soyza","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,3,1]]},"reference":[{"key":"bibr1-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9906120"},{"key":"bibr2-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"bibr3-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400701200"},{"key":"bibr4-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00408.x"},{"key":"bibr5-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.172122"},{"key":"bibr6-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00171409"},{"key":"bibr7-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1086\/590006"},{"key":"bibr8-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-005-4702-1"},{"key":"bibr9-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02453.x"},{"key":"bibr10-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1159\/000228159"},{"key":"bibr11-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03390.x"},{"key":"bibr12-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0642"},{"key":"bibr13-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.10.1316"},{"key":"bibr14-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0375"},{"key":"bibr15-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1086\/591912"},{"key":"bibr16-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02690.x"},{"key":"bibr17-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.016493"},{"key":"bibr18-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwq161"},{"key":"bibr19-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02951.x"},{"key":"bibr20-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03700.x"},{"key":"bibr21-1753425912440472","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2008.00105.x"},{"key":"bibr22-1753425912440472","unstructured":"Caldicott Committee. 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