{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:16:37Z","timestamp":1777731397559,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                    Macrophages have been reported to initiate immunosuppression following trauma and hemorrhage, and recent experimental studies suggest a pivotal role of T-cells in maintaining immunosuppression. The aim of the present study was to investigate the interaction of APC and T-cells in humans following major surgery. First, APC and T-cells from 14 surgical patients were isolated, counted and characterized by their specific surface marker profile 2 and 24\u2009h postoperatively. Then, these cells were co-incubated with cells of the other type, which had been isolated pre-operatively. Chemokine secretion from pre-operative cells as measured by enzyme immunoassay served as a bioassay for the function of the stimulating postoperative cells. CD3\n                    <jats:sup>+<\/jats:sup>\n                    T-cells and surface marker CD28 were markedly suppressed postoperatively, while CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD25\n                    <jats:sup>+<\/jats:sup>\n                    CD127\n                    <jats:sup>\u2212<\/jats:sup>\n                    T\n                    <jats:sub>reg<\/jats:sub>\n                    s were not suppressed. CD14\n                    <jats:sup>+<\/jats:sup>\n                    APC counts were increased with the most significant increase observed in CD14\n                    <jats:sup>+<\/jats:sup>\n                    HLA-DR\n                    <jats:sup>\u2212<\/jats:sup>\n                    myeloid-derived suppressor cells. In co-cultures, APC showed increased postoperative secretion of TNF-\u03b1 and IL-6 independently of whether they had been co-incubated with pre- or postoperative T-cells. T-cells incubated with CD14\n                    <jats:sup>+<\/jats:sup>\n                    cells 2\u2009h postoperatively secreted diminished amounts of IFN-\u03b3. The results of the study suggest that T-cells play a pivotal role in mediating immunosuppression after major abdominal surgery.\n                  <\/jats:p>","DOI":"10.1177\/1753425913516659","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:18:24Z","timestamp":1389140304000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Major surgical trauma differentially affects T-cells and APC"],"prefix":"10.1177","volume":"21","author":[{"given":"Markus","family":"Albertsmeier","sequence":"first","affiliation":[{"name":"Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Klinikum Gro\u00dfhadern, Ludwig-Maximilian University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Quaiser","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Klinikum Gro\u00dfhadern, Ludwig-Maximilian University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"von Dossow-Hanfstingl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Klinikum Gro\u00dfhadern, Ludwig-Maximilian University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Klinikum Gro\u00dfhadern, Ludwig-Maximilian University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Faist","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Klinikum Gro\u00dfhadern, Ludwig-Maximilian University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin K","family":"Angele","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Klinikum Gro\u00dfhadern, Ludwig-Maximilian University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,7]]},"reference":[{"key":"bibr1-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-005-0557-4"},{"key":"bibr2-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318265cf87"},{"key":"bibr3-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-007-0164-7"},{"key":"bibr4-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1177\/1753425909104679"},{"key":"bibr5-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1186\/cc1514"},{"key":"bibr6-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199602000-00001"},{"key":"bibr7-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.277.1.C35"},{"key":"bibr8-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1612"},{"key":"bibr9-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90027-3"},{"key":"bibr10-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1038\/308145a0"},{"key":"bibr11-1753425913516659","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.4049\/jimmunol.147.8.2461","volume":"147","author":"Jenkins MK","year":"1991","journal-title":"J Immunol"},{"key":"bibr12-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200103000-00014"},{"key":"bibr13-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.04.004"},{"key":"bibr14-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18906.x"},{"key":"bibr15-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1177\/1753425909104679"},{"key":"bibr16-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.274.6.C1530"},{"key":"bibr17-1753425913516659","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4514"},{"key":"bibr18-1753425913516659","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1175"},{"key":"bibr19-1753425913516659","doi-asserted-by":"crossref","unstructured":"Chen W, Jin W, Hardegen N, et\u00a0al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor FOXP3.\n                      J Exp Med\n                      2003; 198: 1875\u20131886.","DOI":"10.1084\/jem.20030152"},{"key":"bibr20-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19970101)27:1<71::AID-CYTO9>3.0.CO;2-O"},{"key":"bibr21-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2005.01634.x"},{"key":"bibr22-1753425913516659","first-page":"514","volume":"244","author":"MacConmara MP","year":"2006","journal-title":"Ann Surg"},{"key":"bibr23-1753425913516659","doi-asserted-by":"publisher","DOI":"10.1007\/s001040050324"},{"key":"bibr24-1753425913516659","doi-asserted-by":"crossref","unstructured":"Aneg\u00f3n I, Cuturi MC, Trinchieri G and Perussia B. 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