{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:17:43Z","timestamp":1777731463614,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>The AMP-activated protein kinase (AMPK)-mediated energy-sensing signals play important roles in reprogramming the expression of inflammatory genes. In the present study, the potential effects of the AMPK activator 5-aminoimidazole-4\u2009- carboxamide-1-\u03b2-D-ribofuranoside (AICAR) were investigated in a mouse model with LPS\/D-Gal-induced acute hepatitis. Our experimental data indicated that treatment with AICAR suppressed the elevation of plasma aminotransferases and alleviated the histopathological abnormalities in mice exposed to LPS\/D-Gal. Treatment with AICAR also inhibited the LPS\/D-Gal-induced up-regulation of TNF-\u03b1, NO and myeloperoxidase. In addition, the LPS\/D-Gal-induced expression of pro-apoptotic factor Bax, cleavage of caspase-3, elevation of hepatic caspase-3, caspase-8, caspase-9 activities and induction of terminal deoxynucleotidyl transferase-mediated nucleotide nick-end labeling\u2013positive cells were all suppressed by AICAR. These results suggested that the AMPK activator AICAR could attenuate LPS\/D-Gal-induced acute hepatitis, which implies that AMPK might become a novel target for the treatment of inflammation-based liver disorders.<\/jats:p>","DOI":"10.1177\/1753425915586231","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T22:06:43Z","timestamp":1431727603000},"page":"698-705","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["5-Aminoimidazole-4-carboxamide-1-\u03b2-\n                    <scp>D<\/scp>\n                    -ribofuranoside-attenuates LPS\/\n                    <scp>D<\/scp>\n                    -Gal-induced acute hepatitis in mice"],"prefix":"10.1177","volume":"21","author":[{"given":"Dan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Chongqing Medical University, Chongqing, 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