{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:01:29Z","timestamp":1792587689674,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    Sepsis is a serious clinical condition of excessive systemic immune response to microbial infection. The pro-inflammatory stage of sepsis is generally launched by innate cells such as macrophages. They release inflammatory cytokines, activate other immune cells and cause severe tissue\/organ damage. In this study, we have revealed that recombinant Trichinella spiralis (TS) excretory\u2013secretory protein (rTsP53) exhibited anti-inflammatory properties and rescued mice from LPS-induced endotoxemia, which is a common model for sepsis study, potentially through the induction of M2 macrophages. rTsP53 treatment significantly decreased inflammatory cytokines (IL-6, IFN-\u03b3 and TNF-\u03b1) and increased IL-4, IL-10, IL-13 and TGF-\u03b2 secretion, both in circulation and in tissues. rTsP53 also induced the activation and infiltration of F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    CD163\n                    <jats:sup>+<\/jats:sup>\n                    macrophages to inflammatory tissues, increased M2 macrophage-related Arg1 and Fizz1 expression, and decreased M1 macrophage-related iNOS expression. PCR array showed that rTsP53 activated several genes that involve the survival of macrophages and also anti-inflammatory genes such as SOCS3. Together, our results show that rTsP53 activates M2 macrophages, which has strong anti-inflammatory potential to prevent LPS-induced lethal sepsis.\n                  <\/jats:p>","DOI":"10.1177\/1753425916651984","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T22:00:04Z","timestamp":1466114404000},"page":"419-432","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Recombinant\n                    <i>Trichinella spiralis<\/i>\n                    53-kDa protein activates M2 macrophages and attenuates the LPS-induced damage of endotoxemia"],"prefix":"10.1177","volume":"22","author":[{"given":"Zhi-bin","family":"Chen","sequence":"first","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tang","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-bing","family":"Liang","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-guo","family":"Wu","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-chu","family":"Hu","sequence":"additional","affiliation":[{"name":"Parasitology Laboratory of Northern Campus, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-yu","family":"Li","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-jin","family":"Zeng","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-fu","family":"Ma","sequence":"additional","affiliation":[{"name":"General Internal Medicine Department of The 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"bibr1-1753425916651984","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.133"},{"key":"bibr2-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827c09f8"},{"key":"bibr3-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-0039-8"},{"key":"bibr4-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208623"},{"key":"bibr5-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.79.4"},{"key":"bibr6-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1084\/jem.116.3.381"},{"key":"bibr7-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.3.670"},{"key":"bibr8-1753425916651984","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6166"},{"key":"bibr9-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1995-y"},{"key":"bibr10-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.1.287"},{"key":"bibr11-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015"},{"key":"bibr12-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/262609"},{"key":"bibr13-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150295"},{"key":"bibr14-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/523875"},{"key":"bibr15-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1689-8"},{"key":"bibr16-1753425916651984","first-page":"91","volume":"290","author":"Davies JQ","year":"2005","journal-title":"Methods Mol Biol"},{"key":"bibr17-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2005.05.010"},{"key":"bibr18-1753425916651984","first-page":"221","volume":"44","author":"Jedynak M","year":"2012","journal-title":"Anaesthesiol Intensive Ther"},{"key":"bibr19-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/898646"},{"key":"bibr20-1753425916651984","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13"},{"key":"bibr21-1753425916651984","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.3733"},{"key":"bibr22-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.01.010"},{"key":"bibr23-1753425916651984","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.12.7542"},{"key":"bibr24-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1159\/000364945"},{"key":"bibr25-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.197442"},{"key":"bibr26-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1038\/nri2093"},{"key":"bibr27-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1038\/nri3088"},{"key":"bibr28-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.12.015"},{"key":"bibr29-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117218109"},{"key":"bibr30-1753425916651984","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201168"},{"key":"bibr31-1753425916651984","first-page":"373","volume":"2","author":"Fang M","year":"2005","journal-title":"Cell Mol Immunol"},{"key":"bibr32-1753425916651984","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2014.909456"},{"key":"bibr33-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301328"},{"key":"bibr34-1753425916651984","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2011.12.008"}],"container-title":["Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425916651984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753425916651984","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425916651984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:02:21Z","timestamp":1777460541000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753425916651984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,9]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1177\/1753425916651984"],"URL":"https:\/\/doi.org\/10.1177\/1753425916651984","relation":{},"ISSN":["1753-4259","1753-4267"],"issn-type":[{"value":"1753-4259","type":"print"},{"value":"1753-4267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,9]]}}}