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Thus, deregulation of their expression leads to an inflammatory immune response. Variants of splicing of IL-15R\u03b1 have been described in immune and barrier cells; however, their presence has not been focused on intestinal epithelial cells. In this study, we describe five new alternative variants of splicing of IL-15R\u03b1 in Caco-2 cells. Four of them were expressed into proteins inside Caco-2 cells, but these were unable to bind IL-15 or to follow the secretory pathway. 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