{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:40:53Z","timestamp":1790228453606,"version":"4.1.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>\n                    BMAL1 (brain and muscle ARNT-like protein 1, also known as MOP3 or ARNT3) belongs to the family of the basic helix\u2013loop\u2013helix (bHLH)-PAS domain-containing transcription factors, and is a key component of the molecular oscillator that generates circadian rhythms. Here, we report that BMAL1-deficient cells are significantly more susceptible to infection by two major respiratory viruses of the Paramyxoviridae family, namely RSV and PIV3. Embryonic fibroblasts from Bmal1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice produced nearly 10-fold more progeny virus than their wild type controls. These results were supported by animal studies whereby pulmonary infection of RSV produced a more severe disease and morbidity in Bmal1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice. These results show that BMAL1 can regulate cellular innate immunity against specific RNA viruses.\n                  <\/jats:p>","DOI":"10.1177\/1753425916681075","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T20:15:27Z","timestamp":1480709727000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":71,"title":["Circadian transcription factor BMAL1 regulates innate immunity against select RNA viruses"],"prefix":"10.1177","volume":"23","author":[{"given":"Tanmay","family":"Majumdar","sequence":"first","affiliation":[{"name":"Department of Biological, Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayeeta","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Biological, Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Biological, Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Kondratov","sequence":"additional","affiliation":[{"name":"Department of Biological, Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailen","family":"Barik","sequence":"additional","affiliation":[{"name":"Department of Biological, Geological and Environmental Sciences, and Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"bibr1-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1038\/35088576"},{"key":"bibr2-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-25950-0_1"},{"key":"bibr3-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1021\/bi500731f"},{"key":"bibr4-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5321fje"},{"key":"bibr5-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00722-5"},{"key":"bibr6-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1038\/nature744"},{"key":"bibr7-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00205-1"},{"key":"bibr8-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020377"},{"key":"bibr9-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1432206"},{"key":"bibr10-1753425916681075","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100113"},{"key":"bibr11-1753425916681075","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100633"},{"key":"bibr12-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1038\/nature09253"},{"key":"bibr13-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1099503"},{"key":"bibr14-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.02.003"},{"key":"bibr15-1753425916681075","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100241"},{"key":"bibr16-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318168b76f"},{"key":"bibr17-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02220-06"},{"key":"bibr18-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82187-0"},{"key":"bibr19-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0330OC"},{"key":"bibr20-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01090-09"},{"key":"bibr21-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000228"},{"key":"bibr22-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00220-12"},{"key":"bibr23-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-190"},{"key":"bibr24-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.041129"},{"key":"bibr25-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23193"},{"key":"bibr26-1753425916681075","doi-asserted-by":"publisher","DOI":"10.3390\/v8050124"},{"key":"bibr27-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1144001"},{"key":"bibr28-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000145255.86117.6A"},{"key":"bibr29-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00413-11"},{"key":"bibr30-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1038\/nm1164"},{"key":"bibr31-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"bibr32-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.112"},{"key":"bibr33-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.02.003"},{"key":"bibr34-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.002"},{"key":"bibr35-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240636"},{"key":"bibr36-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601895113"},{"key":"bibr37-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206274109"},{"key":"bibr38-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209965109"},{"key":"bibr39-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1108125108"},{"key":"bibr40-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15623"},{"key":"bibr41-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120231"},{"key":"bibr42-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00066.2007"},{"key":"bibr43-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2013.06.003"},{"key":"bibr44-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214441110"},{"key":"bibr45-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.2.1113-1124.2005"},{"key":"bibr46-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005318"},{"key":"bibr47-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005622"},{"key":"bibr48-1753425916681075","first-page":"173","volume":"372","author":"Barik S","year":"2013","journal-title":"Curr Top Microbiol Immunol"},{"key":"bibr49-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.98"},{"key":"bibr50-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.11.015"},{"key":"bibr51-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05360-11"},{"key":"bibr52-1753425916681075","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.09.016"}],"container-title":["Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425916681075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753425916681075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425916681075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:02:29Z","timestamp":1777460549000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753425916681075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,5]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/1753425916681075"],"URL":"https:\/\/doi.org\/10.1177\/1753425916681075","relation":{},"ISSN":["1753-4259","1753-4267"],"issn-type":[{"value":"1753-4259","type":"print"},{"value":"1753-4267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,5]]}}}