{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:20:18Z","timestamp":1779312018599,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    Our aim was to examine the effect of low-volume 0.9% NaCl adenosine, lidocaine and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    (ALM) \u2018drip\u2019 on early immune-inflammatory activation after a single laparotomy with no further manipulation. Male Sprague\u2013Dawley rats were anesthetized and randomly assigned to one of the groups, baseline, 1\u2009h infusion 0.9% NaCl\u2009\u00b1\u2009ALM and metrics, 1\u2009h infusion and 6-h metrics, and 6\u2009h continuous infusion and metrics. Complete blood count, acid\u2013base balance, systemic levels of IL-6 and IL-10, and coagulation status were measured. After 1\u2009h, there was a disproportionate increase in circulating neutrophils between saline and ALM groups despite an identical 45% fall in lymphocytes. Disproportionate increases also occurred in platelet counts 1\u2009h after surgery, and saline controls had increased respiratory alkalosis at 6\u2009h with higher lactate. Systemic inflammation was also evident after 1\u2009h in both groups (plasma IL-6 increase) and was amplified in saline-controls after 6\u2009h. The ALM group increased anti-inflammatory cytokine IL-10. Surgery was not associated with acute coagulopathy; however, there were significant reductions in fibrinolysis. Following a single laparotomy, ALM infusion appeared to reduce stress-induced release of neutrophils and platelets into the circulation, and reduced acid\u2013base disturbance. After 1\u2009h, both groups had similar IL-6 levels, but ALM animals had increased IL-10, indicating improved inflammatory balance. The uncoupling of inflammation and coagulation activation but not fibrinolysis may offer a unique opportunity to investigate differential activation of innate immunity in response to sterile injury in this model.\n                  <\/jats:p>","DOI":"10.1177\/1753425917718921","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T09:41:58Z","timestamp":1510047718000},"page":"482-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg\n                    <sup>2+<\/sup>\n                    infusion to dampen the stress response"],"prefix":"10.1177","volume":"23","author":[{"given":"Lisa","family":"Davenport","sequence":"first","affiliation":[{"name":"Heart, Trauma and Sepsis Research Laboratory, College of Medicine and Dentistry, James Cook University, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley L","family":"Letson","sequence":"additional","affiliation":[{"name":"Heart, Trauma and Sepsis Research Laboratory, College of Medicine and Dentistry, James Cook University, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey P","family":"Dobson","sequence":"additional","affiliation":[{"name":"Heart, Trauma and Sepsis Research Laboratory, College of Medicine and Dentistry, James Cook University, Queensland, 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