{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:26:51Z","timestamp":1789943211018,"version":"4.0.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>The objective of this study was to investigate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting short-term therapeutic response to methotrexate (MTX) in rheumatoid arthritis (RA). Patients with active RA, with Disease Activity Score-28 joints (DAS-28) &gt;3.2, starting oral MTX, were included. We measured at baseline, 3 and 6\u2009mo: DAS-28, Health Assessment Questionnaire\u2013Disability Index (HAQ-DI), patient\u2019s perception of disease severity, morning stiffness and pain, as well as modifications in sTREM-1 levels. A reduction in DAS-28\u2009&gt;\u20091.2 at 3 or 6\u2009mo was considered adequate response. A significant decrease in DAS-28 was observed at 3 and 6\u2009mo. HAQ-DI also decreased at 3 and 6\u2009mo. No significant changes were observed in sTREM-1 levels at 3 or 6\u2009mo. Using as cut-off a baseline value of sTREM-1 levels\u2009&gt;\u2009390\u2009pg\/ml, we obtained low values of sensitivity (61.5%), specificity (59.3%), positive predictive value (59.3%) and negative predictive value (61.5%) for adequate response to MTX at 3 mo. We found no clinical value of sTREM-1 levels in predicting therapeutic response to MTX in RA. Further studies should evaluate if sTREM-1 levels are predictive for other outcomes, including higher structural damage or good response to biologics.<\/jats:p>","DOI":"10.1177\/1753425917726862","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:58:23Z","timestamp":1504720703000},"page":"606-614","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Utility of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as biomarker to predict therapeutic response to methotrexate in rheumatoid arthritis"],"prefix":"10.1177","volume":"23","author":[{"given":"Jorge I.","family":"Gamez-Nava","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica 02, UMAE, Hospital de Especialidades. Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bonilla-Lara","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna-Reumatolog\u00eda, Hospital General Regional 110 del IMSS, Guadalajara, M\u00e9xico"},{"name":"Doctorado en Farmacolog\u00eda y Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Ponce-Guarneros","sequence":"additional","affiliation":[{"name":"Unidad M\u00e9dica Familiar 97, del IMSS, Magdalena, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alejandro","family":"Zu\u00f1iga-Mora","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna-Reumatolog\u00eda, Hospital General Regional 110 del IMSS, Guadalajara, M\u00e9xico"},{"name":"Programa de Servicio Social, CUCS, Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edsaul E.","family":"Perez-Guerrero","sequence":"additional","affiliation":[{"name":"Doctorado en Farmacolog\u00eda y Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, M\u00e9xico"},{"name":"Departamento de Farmacobiolog\u00eda, Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D.","family":"Murillo-Vazquez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica 02, UMAE, Hospital de Especialidades. Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, M\u00e9xico"},{"name":"Doctorado en Farmacolog\u00eda y Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzel N.","family":"Becerra-Alvarado","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica 02, UMAE, Hospital de Especialidades. Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, M\u00e9xico"},{"name":"Doctorado en Farmacolog\u00eda y Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Alejandra","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna-Reumatolog\u00eda, Hospital General Regional 110 del IMSS, Guadalajara, M\u00e9xico"},{"name":"Doctorado en Farmacolog\u00eda y Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Miriam","family":"Salda\u00f1a-Cruz","sequence":"additional","affiliation":[{"name":"Doctorado en Farmacolog\u00eda y Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, M\u00e9xico"},{"name":"Divisi\u00f3n de Ciencias de la Salud, Departamento de Ciencias Biom\u00e9dicas, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Tonal\u00e1, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Luisa","family":"Vazquez-Villegas","sequence":"additional","affiliation":[{"name":"Departamento de Epidemiolog\u00eda, Unidad M\u00e9dica Familiar 4, del IMSS, Guadalajara, M\u00e9xico"},{"name":"Instituto Regional de Investigaci\u00f3n en Salud Publica del Departamento de Salud P\u00fablica, CUCS, Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Y.","family":"Vera-Navarrete","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna-Reumatolog\u00eda, Hospital General Regional 110 del IMSS, Guadalajara, M\u00e9xico"},{"name":"Doctorado en Farmacolog\u00eda y Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Gonzalez-Ponce","sequence":"additional","affiliation":[{"name":"Departamento de Medicina 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