{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:20:20Z","timestamp":1777731620969,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Poznan University of Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The aim of this study is to describe the prevalence of single single-nucleotide polymorphisms (SNPs) as well as their combinations in genes encoding proteins involved in the immune response in children with bacterial meningitis. The prospective study group consisted of 39 children with bacterial meningitis and 49 family members surveyed between 2012 and 2016. Eleven SNPs in seven genes involved in immune response were analysed. The mean number of minor frequency alleles (MAF) of studied SNPs was lowest in the control group and highest in patients with pneumococcal meningitis. We found that carrying \u22656 MAF of studied SNPs was associated with an increased risk of pneumococcal meningitis. The prevalence of risky variants was noted to be higher in patients with pneumococcal meningitis as compared to the control group. In conclusion, genetic factors are a relevant factor in determining the susceptibility to bacterial meningitis. A statistically significant cumulative effect of mutated variants on increasing the risk of bacterial meningitis was detected. Combining all three SNPs in MBL2 improves the prediction of susceptibility to pneumococcal meningitis. Analysis of risky alleles can help indicate people prone to the disease who are \u2018gene-immunocompromised\u2019.<\/jats:p>","DOI":"10.1177\/1753425918762038","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:50:12Z","timestamp":1520988612000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["How many single-nucleotide polymorphisms (SNPs) must be tested in order to prove susceptibility to bacterial meningitis in children? Analysis of 11 SNPs in seven genes involved in the immune response and their effect on the susceptibility to bacterial meningitis in children"],"prefix":"10.1177","volume":"24","author":[{"given":"Ewelina","family":"Gowin","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Poznan University of Medical Sciences, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogna","family":"\u015awi\u0105tek-Ko\u015bcielna","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Ka\u0142u\u017cna","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Strauss","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Poznan University of Medical Sciences, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Nowak","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Michalak","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Poznan University of Medical Sciences, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta","family":"Januszkiewicz-Lewandowska","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Polish Academy of Sciences, Poznan Poland"},{"name":"Department of Oncology, Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"bibr1-1753425918762038","unstructured":"World Health Organization. Surveillance for vaccine preventable diseases (VPDs), http:\/\/www.who.int\/immunization\/monitoring_surveillance\/burden\/VPDs\/en\/ (accessed 22 December 2016)."},{"key":"bibr2-1753425918762038","unstructured":"Centers for Disease Control and Prevention. Active bacterial core surveillance report, emerging infections program network,\n                      Neisseria meningitidis\n                      , https:\/\/www.cdc.gov\/abcs\/reports-findings\/survreports\/mening14.pdf, (accessed 22 December 2016)."},{"key":"bibr3-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1258308"},{"key":"bibr4-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61187-8"},{"key":"bibr5-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70251-6"},{"key":"bibr6-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.05.002"},{"key":"bibr7-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064252"},{"key":"bibr8-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70045-1"},{"key":"bibr9-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1038\/ng.640"},{"key":"bibr10-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600643203"},{"key":"bibr11-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08350-0"},{"key":"bibr12-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2012.01095.x"},{"key":"bibr13-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08516-1"},{"key":"bibr14-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12745"},{"key":"bibr15-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1086\/342845"},{"key":"bibr16-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1105626"},{"key":"bibr17-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1086\/656236"},{"key":"bibr18-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1038\/ng1976"},{"key":"bibr19-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1086\/507907"},{"key":"bibr20-1753425918762038","unstructured":"1000 Genomes Project (http:\/\/www.ensembl.org) (accessed 1 October 2017)."},{"key":"bibr21-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035837"},{"key":"bibr22-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.04.024"},{"key":"bibr23-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100155"},{"key":"bibr24-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq155"},{"key":"bibr25-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu276"},{"key":"bibr26-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1086\/340216"},{"key":"bibr27-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(98)80037-5"},{"key":"bibr28-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000256751.76218.7c"},{"key":"bibr29-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01110-09"},{"key":"bibr30-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000095431.15606.68"},{"key":"bibr31-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1031605100"},{"key":"bibr32-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01163.x"},{"key":"bibr33-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00615-08"},{"key":"bibr34-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007374"},{"key":"bibr35-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1086\/322798"},{"key":"bibr36-1753425918762038","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120757"}],"container-title":["Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425918762038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753425918762038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425918762038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:02:41Z","timestamp":1777460561000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753425918762038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,13]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/1753425918762038"],"URL":"https:\/\/doi.org\/10.1177\/1753425918762038","relation":{},"ISSN":["1753-4259","1753-4267"],"issn-type":[{"value":"1753-4259","type":"print"},{"value":"1753-4267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,13]]}}}