{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:22:04Z","timestamp":1778685724124,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    The present study investigated clinical and immunological modulations due to intramuscular injection of Escherichia coli LPS in 49-wk-old laying hens over 48 h post injection (p.i.). LPS induced characteristic sickness behavior but no significant body temperature alterations ( P\u2009&gt;\u20090.05). During experimental period decreases in blood albumin, calcium, phosphorus and tryptophan concentrations, hyperglycemia, increased plasma nitrite concentrations, leucopenia, decreased thrombocyte counts, lymphopenia, heterophilia and an increased heterophilic granulocyte\/lymphocyte (H\/L) ratio were observed after LPS administration. Time-dependent effects were shown on T and B cell subsets in caecal tonsils (CT) and on splenic CD3\n                    <jats:sup>+<\/jats:sup>\n                    \/CD4\n                    <jats:sup>+<\/jats:sup>\n                    \/CD8\n                    <jats:sup>+<\/jats:sup>\n                    proportions, on IL-1\u03b2 and -10 and inducible NO synthase mRNA expression in peripheral blood lymphocytes (PBL), liver, spleen and CT, and on the mRNA expression of the TLR4 in PBL, liver and spleen p.i. ( P\u2009&lt;\u20090.05). The main responding period of mentioned alterations due to LPS appears to include the period from 2 until 8 h p.i. According to the H\/L ratio, the most stressful phase was 5 h p.i. T and B cell subsets in CT, the IL-1\u03b2 and TLR4 mRNA expression in liver and plasma nitrite concentrations seemed to be affected for a longer period.\n                  <\/jats:p>","DOI":"10.1177\/1753425919835296","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T21:33:00Z","timestamp":1553117580000},"page":"186-202","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Kinetic studies on clinical and immunological modulations by intramuscular injection of\n                    <i>Escherichia coli<\/i>\n                    LPS in laying hens"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3172-4074","authenticated-orcid":false,"given":"Wendy","family":"Liermann","sequence":"first","affiliation":[{"name":"Institute of Nutritional Physiology, \u201cOskar Kellner\u201d, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Frahm","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Brunswick, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Halle","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Brunswick, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"B\u00fchler","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Brunswick, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Kluess","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Brunswick, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liane","family":"H\u00fcther","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Brunswick, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"D\u00e4nicke","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Brunswick, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"bibr1-1753425919835296","doi-asserted-by":"publisher","DOI":"10.1177\/09680519010070030101"},{"key":"bibr2-1753425919835296","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12466"},{"key":"bibr3-1753425919835296","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.2005.B1045"},{"key":"bibr4-1753425919835296","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/79.1.33"},{"key":"bibr5-1753425919835296","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(93)90215-2"},{"key":"bibr6-1753425919835296","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pev359"},{"key":"bibr7-1753425919835296","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1055\/s-0038-1622689","volume":"36","author":"Pendl H.","year":"2008","journal-title":". 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