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Here, we cloned and identified the TRAF6 gene from the King pigeon. The open reading frame sequence of pigeon TRAF6 (piTRAF6) is 1638 bp long and encodes a 545 aa protein, including a low-complexity domain, RING finger, Zinc finger, coiled coil domain, and meprin and TRAF homology domain. The aa sequence of piTRAF6 shared a strong identity with that of other birds. PiTRAF6 transcripts were broadly expressed in all the tested tissues; piTRAF6 levels were the highest and lowest in the heart and stomach, respectively. Overexpression of piTRAF6 activated NF-\u03baB in a dose-dependent manner and induced IFN-\u03b2 expression. Upon piTRAF6 knockdown by small interfering RNAs, NF-\u03baB activation was markedly inhibited in HEK293T cells. The expression of piTRAF6, as well as pro-inflammatory cytokines and antiviral molecules, were obviously increased after TLR ligand stimulation and Newcastle disease virus or Salmonella Pullorum inoculation. These results suggest that piTRAF6 may play a key immunoregulatory role in the innate immune response against viral and bacterial infections.<\/jats:p>","DOI":"10.1177\/1753425920920930","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T01:06:52Z","timestamp":1589245612000},"page":"490-504","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular characterisation, expression and functional feature of TRAF6 in the King pigeon (\n                    <i>Columba livia<\/i>\n                    )"],"prefix":"10.1177","volume":"26","author":[{"given":"Yaxin","family":"Guo","sequence":"first","affiliation":[{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, PR China"},{"name":"Jiangsu Key Laboratory of Zoonosis, Yangzhou University, PR China"},{"name":"Key Laboratory of Prevention and 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