{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:22:44Z","timestamp":1777731764577,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Psoriasis vulgaris (PsV) is an immune-mediated inflammatory disorder with devastating psychosocial consequences. Expression of immunoregulator molecules on leukocytes in PsV remains unclear. Leukocyte-associated Ig-like receptor-1 (LAIR-1) and complement receptor-1 (CR-1) are immunoregulator receptors reported to bind complement component 1q involved in phagocytosis. We aimed to explore if altered leukocyte expression of LAIR-1 and CR-1 is associated with PsV. This case\u2013control study included 36 PsV patients and 36 healthy controls. Neutrophils, monocytes and B and T cells were examined by flow cytometry for LAIR-1 and CR-1 mean fluorescence intensity (MFI) and positive cell percentage. Comparison between both groups revealed a significant decrease in LAIR-1 MFI on neutrophils and T cells ( P\u2009&lt;\u20090.001 and P\u2009=\u20090.003, respectively). CR-1 MFI on neutrophils, monocytes and T cells also showed a significant decrease in patients ( P\u2009=\u20090.033, P\u2009=\u20090.001 and P\u2009=\u20090.040, respectively). There was a significant positive correlation of LAIR-1 MFI on neutrophils with CR-1 MFI on neutrophils ( r\u2009=\u20090.503; P\u2009=\u20090.002) and LAIR-1 MFI on monocytes with CR-1 MFI on monocytes ( r\u2009=\u20090.371; P\u2009=\u20090.026). Receiver operating characteristic curves revealed that CR-1 MFI on monocytes had the highest discrimination power to differentiate patients from controls, with 86.1% specificity and 75% sensitivity ( P\u2009=\u20090.001). In conclusion, altered leukocytes expression of LAIR-1 and CR-1 is associated with PsV. Down-regulated CR-1 MFI on monocytes is a promising diagnostic biomarker for PsV.<\/jats:p>","DOI":"10.1177\/1753425920942570","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:32:56Z","timestamp":1596155576000},"page":"683-692","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Immunoregulatory complement receptor-1 and leukocyte-associated Ig-like receptor-1 expression on leukocytes in\n                    <i>Psoriasis vulgaris<\/i>"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-9106","authenticated-orcid":false,"given":"Reham","family":"Hammad","sequence":"first","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervat","family":"Hamdino","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Departmet, Faculty of Medicine (for Girls), Al-Azhar University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa M","family":"El-Nasser","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Immunology Department, Faculty of Medicine (for Girls), Al-Azhar University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Sobhy","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine (Assiut), Al-Azhar University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha Abdel-Rahman","family":"Eldesoky","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy (for Girls), Al-Azhar University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-243X","authenticated-orcid":false,"given":"Alya Mohammad","family":"Mashaal","sequence":"additional","affiliation":[{"name":"Immunology, Zoology and Entomology Department, Faculty of Science (for Girls), Al-Azhar University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany F","family":"Ali","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine (for Boys), Al-Azhar University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"bibr1-1753425920942570","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.82"},{"key":"bibr2-1753425920942570","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02376"},{"key":"bibr3-1753425920942570","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/idoj.IDOJ_169_19","volume":"11","author":"Shah BJ","year":"2020","journal-title":"Indian Dermatol Online J"},{"key":"bibr4-1753425920942570","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01764"},{"key":"bibr5-1753425920942570","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.07.007"},{"key":"bibr6-1753425920942570","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"bibr7-1753425920942570","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.12.010"},{"key":"bibr8-1753425920942570","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907609"},{"key":"bibr9-1753425920942570","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701753"},{"key":"bibr10-1753425920942570","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00185"},{"key":"bibr11-1753425920942570","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13100"},{"key":"bibr12-1753425920942570","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1923"},{"key":"bibr13-1753425920942570","doi-asserted-by":"crossref","unstructured":"Luk\u00e1csi S, M\u00e1csik-Valent B, Nagy-Bal\u00f3 Z, et\u00a0al. 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