{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:23:30Z","timestamp":1777731810087,"version":"3.51.4"},"reference-count":90,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Both innate immunity and acquired immunity are involved in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The induction of Abs that neutralize the virus has been described, and certain Abs against endemic coronaviruses may cross-react with SARS-CoV-2. Detailed mechanisms to protect against the pandemic of SARS-CoV-2 remain unresolved. We previously reported that IgG Fc-binding protein (Fc\u03b3bp), a unique, large molecular weight, and mucin-like secretory Fc receptor protein, secreted from goblet cells of human small and large intestine, mediates the transportation of serum IgG onto the mucosal surface. In this review, we show that mucous bronchial gland cells and some goblet cells are immunoreactive for Fc\u03b3bp. Fc\u03b3bp traps the cross-reactive (both neutralizing and non-neutralizing) IgG bound to the virus and can consequently eliminate the virus from the mucosal surface to decrease viral loads. Fc\u03b3bp can also suppress immune overreaction by interfering with Fc-binding by macrophages and competing with complement fixation. Fc\u03b3bp secreted from mucin-producing cells of the airway functions as an important anti-infection mucosal defense. The Fc\u03b3bp-mediated mechanism can be a key factor in explaining why SARS-CoV-2 is less infective\/lethal in children, and may also be involved in the unique Ab response, recurrent infection, and effects of serum therapy and vaccination.<\/jats:p>","DOI":"10.1177\/17534259211043159","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T03:31:42Z","timestamp":1631676702000},"page":"423-436","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in protecting against SARS-CoV-2 infection"],"prefix":"10.1177","volume":"27","author":[{"given":"Kensuke","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Kobayashi Clinic, Kure, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-0391","authenticated-orcid":false,"given":"Mitsuhiro","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Shimada General Medical Center, Shimada, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-9678","authenticated-orcid":false,"given":"Yutaka","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Shimada General Medical Center, Shimada, Shizuoka, Japan"},{"name":"Diagnostic Pathology Clinic, Pathos Tsutsumi, Inazawa, Aichi, Japan"},{"name":"Yokkaichi Nursing and Health Care University, School of Medical Technology, Yokkaichi, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"bibr1-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"bibr2-17534259211043159","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.640073"},{"key":"bibr3-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.4616"},{"key":"bibr4-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0897-1"},{"key":"bibr5-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0965-6"},{"key":"bibr6-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.10.023"},{"key":"bibr7-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02374-20"},{"key":"bibr8-17534259211043159","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.4049\/jimmunol.143.8.2567","volume":"143","author":"Kobayashi K","year":"1989","journal-title":"J Immunol"},{"key":"bibr9-17534259211043159","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4049\/jimmunol.146.1.68","volume":"146","author":"Kobayashi K","year":"1991","journal-title":"J Immunol"},{"key":"bibr10-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.169"},{"key":"bibr11-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.005"},{"key":"bibr12-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143380"},{"key":"bibr13-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.04.009"},{"key":"bibr14-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-00997-6"},{"key":"bibr15-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0485-4"},{"key":"bibr16-17534259211043159","first-page":"10004","volume":"1","author":"Suthar MS","year":"2020","journal-title":"Cell Rep Med"},{"key":"bibr17-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2598-9"},{"key":"bibr18-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.015"},{"key":"bibr19-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.044"},{"key":"bibr20-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107725"},{"key":"bibr21-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01991-20"},{"key":"bibr22-17534259211043159","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe1107"},{"key":"bibr23-17534259211043159","doi-asserted-by":"crossref","unstructured":"Kobayashi K, Brown WR. Study of colonic IgG Fc binding site in cultured epithelial cells.\n                      Digest Dis Sci\n                      1994; 39: 526\u2013533.","DOI":"10.1007\/BF02088337"},{"key":"bibr24-17534259211043159","doi-asserted-by":"crossref","unstructured":"Kim YS, Ho SB. 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Sero-monitoring of health care workers reveals complex relationships between common coronavirus antibodies and SARS-CoV-2 severity.\n                      medRxiv\n                      . Epub ahead of print 19 April 2021. 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Asthma and risk of infection, hospitalization, ICU admission and mortality from COVID-19: systematic review and meta-analysis.\n                      J Asthma\n                      . Epub ahead of print 1 April 2021. 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