{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:08:51Z","timestamp":1793239731849,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Malaria is often characterized by a complicated disease course due to multifaceted intrinsic genetic factors of the host and the parasite. This study aimed to investigate the role of interleukin-27 ( IL-27) gene polymorphisms in Plasmodium falciparum malaria infection in a Saudi Arabian cohort. This case-control study obtained blood samples from 250 malaria patients with P. falciparum and 200 randomly identified healthy control subjects from the Malaria Center in the Jazan area. Malaria patients were grouped into three cohorts as follow: low (&lt;500 parasites\/\u00b5l of blood), moderate (500\u20131000 parasites\/\u00b5l of blood), and high (&gt;1000 parasites\/\u00b5l of blood) parasitemia. The results show that the IL-27 variant rs181209 was significantly associated with malaria patients ( P\u2009=\u20090.026). Similarly, the homozygous GG genotype of rs26528 was also associated with risk of developing P. falciparum malaria ( P\u2009=\u20090.032). The minor allele C of variant rs181206 exhibited an association with low to moderate parasitemia ( P\u2009=\u20090.046). Furthermore, the rs181209 AA genotype was statistically significant in age group 1\u20135 years ( P\u2009=\u20090.049). In conclusion, this study suggests that variant rs181209 and rs26528 could be associated with the risk of malaria infection by P. falciparum in the population studied.<\/jats:p>","DOI":"10.1177\/17534259231178594","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T07:03:06Z","timestamp":1686553386000},"page":"83-94","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between interleukin-27 gene polymorphisms and\n                    <i>Plasmodium falciparum<\/i>\n                    Malaria"],"prefix":"10.1177","volume":"29","author":[{"given":"Nada H.","family":"Aljarba","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashael 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