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Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-\u03baB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    \/LysMCre mice do not exhibit differences in na\u00efve systemic immune profiles or colony forming units and time to death following Salmonella infection as compared to controls. Additionally, p65\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    \/LysMCre mice, especially females, display splenomegaly, but no other obvious physical or behavioral differences as compared to control animals. As bone marrow-derived macrophages from this transgenic model are almost completely devoid of canonical nuclear factor-kappaB pathway member p65, this model has the potential for being very useful in investigating bone marrow-derived macrophage NF-kappaB signaling in diverse biological and biomedical studies.\n                  <\/jats:p>","DOI":"10.1177\/17534259231205993","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:18:31Z","timestamp":1697167111000},"page":"171-185","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Production of a p65\n                    <sup>fl\/fl<\/sup>\n                    \/LysMCre mouse model with dysfunctional NF-\u03baB signaling in bone marrow-derived macrophages"],"prefix":"10.1177","volume":"29","author":[{"given":"Ahmet K.","family":"Korkaya","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Augusta University, Augusta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Augusta University, Augusta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Peppers","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Augusta University, Augusta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean M.","family":"Crosson","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manira","family":"Rayamajhi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"bibr1-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800249-0.00003-2"},{"key":"bibr2-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1228704"},{"key":"bibr3-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071914"},{"key":"bibr4-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01095.x"},{"key":"bibr5-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000034"},{"key":"bibr6-17534259231205993","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00705"},{"key":"bibr7-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"bibr8-17534259231205993","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1134661"},{"key":"bibr9-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1038\/376167a0"},{"key":"bibr10-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011885"},{"key":"bibr11-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-486142"},{"key":"bibr12-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00067.2013"},{"key":"bibr13-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00532.2014"},{"key":"bibr14-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2935"},{"key":"bibr15-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008942828960"},{"key":"bibr16-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1038\/srep28340"},{"key":"bibr17-17534259231205993","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00078.2016"},{"key":"bibr18-17534259231205993","volume":"72","author":"Lee 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