{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:17:13Z","timestamp":1783808233355,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,9,3]],"date-time":"2008-09-03T00:00:00Z","timestamp":1220400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p> Background: Oxidative stress is presumed to impair \u03b2-adenoceptor function and airway patency. Erdosteine (E), a mucomodulatory compound, has shown important antioxidant properties. <\/jats:p><jats:p> Methods: The objective was to assess the effect of antioxidant interventions on short-term airway response to salbutamol in non-reversible mild-to-moderate COPD patients. Thirty COPD patients (GOLD class 1\u20142), current smoker (\u226510 pack\/year), randomly received E 300 mg, N-acetylcysteine (NAC) 600 mg, or placebo, twice daily for ten days. Reversibility to salbutamol 200 \u03bcg was tested in baseline, after four and ten days of each treatment. ROS and 8-isoprostane blood levels were measured on the same days. Between-treatment comparison was performed by ANOVA and t-test or Wilcoxon test, and p&lt;0.05 assumed. E enhanced FEV1 reversibility after four and ten days significantly (+5.1% and +5.0%; both p&lt;0.01 vs. placebo), while NAC only showed a transient effect at day 4 (+3.0%, p&lt;0.05), but not at day 10 (+1.3%, p = ns). <\/jats:p><jats:p> Results: E and NAC caused significant drops in ROS blood levels after four and ten days (p&lt;0.001 and p&lt;0.0001 vs. placebo). In contrast to NAC, E lowered 8-isoprostane levels substantially for ten days (p = 0.017 and p = 0.0004 vs. placebo, respectively). Only E restored significantly short-term reversibility in COPD patients previously unresponsive to \u03b2<jats:sub>2<\/jats:sub>-adrenergics. <\/jats:p><jats:p> Conclusions: This effect seems more related to the peculiar protection against lipid peroxidation rather than to the scavenging activity, which proves equal to that of NAC. E provides a sort of indirect bronchodilation through 're-sensitisation' of \u03b2<jats:sub> 2<\/jats:sub>-adrenoceptors. Once confirmed in further controlled studies, it may be useful in long-term treatment of COPD. <\/jats:p>","DOI":"10.1177\/1753465808096109","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T00:25:48Z","timestamp":1220487948000},"page":"271-277","source":"Crossref","is-referenced-by-count":16,"title":["Erdosteine enhances airway response to salbutamol in patients with                 mild-to-moderate COPD"],"prefix":"10.1177","volume":"2","author":[{"given":"Roberto","family":"Dal Negro","sequence":"first","affiliation":[{"name":"Lung Department, Orlandi General Hospital, Bussolengo, Verona, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Visconti","sequence":"additional","affiliation":[{"name":"Orlandi General Hospital, UOC Pneumologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenza","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Orlandi General Hospital, UOC Pneumologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bertacco","sequence":"additional","affiliation":[{"name":"Orlandi General Hospital, UOC Pneumologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Micheletto","sequence":"additional","affiliation":[{"name":"Orlandi General Hospital, UOC Pneumologia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tognella","sequence":"additional","affiliation":[{"name":"Orlandi General Hospital, UOC Pneumologia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,9,3]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00102604"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.2165\/00126839-200506020-00003"},{"key":"atypb3","first-page":"344","volume":"49","author":"Braga, P.C.","year":"1999","journal-title":"Arzneim-Forsch\/Drug Res"},{"key":"atypb4","first-page":"739","volume":"50","author":"Braga, P.C.","year":"2000","journal-title":"Arzneim-Forsch\/Drug Res"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.8.659"},{"key":"atypb6","first-page":"199","volume":"57","author":"Dal Negro, R.W.","year":"2003","journal-title":"It J Chest Dis"},{"issue":"2","key":"atypb7","first-page":"89","volume":"171","author":"Dal Negro, R.W.","year":"2005","journal-title":"Am J Crit Care Med"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2007.07.004"},{"key":"atypb9","first-page":"147","volume":"28","author":"Dal Sasso, M.","year":"2002","journal-title":"Drugs Exptl Clin Res"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00016804"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118977"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02719705"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050447"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2006.12.006"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2006.12.006"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.O-06-431"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:43:1:167"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.2147\/copd.2006.1.1.15"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1177\/039463200601900318"},{"key":"atypb20","first-page":"3","volume":"4","author":"van Hoof, I.H.","journal-title":"Cent Eur J Public Health"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753465808096109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753465808096109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T18:11:19Z","timestamp":1740939079000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753465808096109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,3]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1177\/1753465808096109"],"URL":"https:\/\/doi.org\/10.1177\/1753465808096109","relation":{},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,3]]}}}