{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:20:34Z","timestamp":1770999634652,"version":"3.50.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p> Background: During winter 2009 we treated with prolonged corticosteroid infusion eight consecutive patients affected by H1N1-virus infection and severe pneumonia. The most severe patient was a previously healthy 30-year-old man admitted to hospital because of bilateral pneumonia and severe acute respiratory failure. <\/jats:p><jats:p> Method: H1N1-virus infection was detected by broncho-alveolar lavage performed on day 1. After some days following admission the patient was still in a life-threatening state, not responding to oseltamivir, protective mechanical ventilation and veno-arterial extracorporeal membrane oxygenation (ECMO). <\/jats:p><jats:p> Results: The addition of methylprednisolone infusion at a stress dose (1 mg\/kg\/24 h) as rescue therapy significantly and rapidly improved the clinical condition. Weaning from ECMO and invasive mechanical ventilation was possible within a relatively few days. <\/jats:p><jats:p> Conclusion: According to the literature reports more than 34% of H1N1-virus severe infections were treated with corticosteroids. This report and our experience may suggest a possible life-saving use of corticosteroids at a stress dose in severely ill patients with an H1N1-virus infection that is not responding to the most advanced treatments. <\/jats:p>","DOI":"10.1177\/1753465810376951","type":"journal-article","created":{"date-parts":[[2010,7,17]],"date-time":"2010-07-17T00:58:55Z","timestamp":1279328335000},"page":"233-237","source":"Crossref","is-referenced-by-count":18,"title":["Methylprednisolone infusion for life-threatening H1N1-virus infection"],"prefix":"10.1177","volume":"4","author":[{"given":"Marco","family":"Confalonieri","sequence":"first","affiliation":[{"name":"Pneumology Department, University Hospital of Cattinara, Str. Di Fiume 447, 34149 Trieste, Italy,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Cifaldi","sequence":"additional","affiliation":[{"name":"Pneumology Department, University Hospital of Cattinara, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorella","family":"Dreas","sequence":"additional","affiliation":[{"name":"Cardiosurgery, University Hospital of Cattinara, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marino","family":"Viviani","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital of Cattinara, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Biolo","sequence":"additional","affiliation":[{"name":"Pneumology Department, University Hospital of Cattinara, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Cardiosurgery, University Hospital of Cattinara, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.815"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47124-0"},{"key":"atypb3","first-page":"749","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2010.tb03426.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.12.012"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-808OC"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1536"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.3201\/eid1601.090941"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906695"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61528-2"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1496"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31817603ba"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904252"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1727-6"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1186\/cc8044"},{"key":"atypb16","first-page":"156","volume":"22","author":"Sun, J.J.","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819fb507"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc0905545"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908481"},{"key":"atypb20","volume-title":"Clinical Management of Human Infection with Pandemic (H1N1) 2009: Revised Guidance","author":"World Health Organization","year":"2009"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753465810376951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753465810376951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T21:42:17Z","timestamp":1737754937000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753465810376951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,16]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1177\/1753465810376951"],"URL":"https:\/\/doi.org\/10.1177\/1753465810376951","relation":{},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,16]]}}}