{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:01:30Z","timestamp":1773392490932,"version":"3.50.1"},"reference-count":55,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T00:00:00Z","timestamp":1314921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p> Rationale: Previous studies have demonstrated that long-term low-dose macrolides are efficacious in cystic fibrosis (CF) and diffuse panbronchiolitis, two chronic neutrophilic airway diseases. <\/jats:p><jats:p> Aims: The aims of this study were to evaluate the efficacy and safety of low-dose neomacrolides as add-on therapy in patients with severe asthma and\/or bronchiectasis and to identify predictors for therapeutic response. <\/jats:p><jats:p> Methods: In a retrospective observational cohort study, we examined 131 adult, non-CF patients with severe asthma and\/or bronchiectasis, receiving low-dose neomacrolides as add-on treatment. Pulmonary function tests and symptom scores were assessed at baseline and after 3 to 8 weeks of therapy. <\/jats:p><jats:p> Results: After 3\u20138 weeks of treatment with low-dose neomacrolides, 108 patients were available for evaluation. In asthma patients ( n = 47), pulmonary function tests and symptom scores improved significantly. Responders (\u22657% forced expiratory volume in one second predicted [FEV<jats:sub>1<\/jats:sub>%] improvement) were older (55 vs. 47 years; p = 0.042) and had a longer duration of asthma (29 vs. 9 years; p = 0.052). In patients with bronchiectasis only ( n = 61), symptom scores improved significantly. Responders (\u226560% symptom score improvement) were older (61 vs. 53 years; p = 0.004), more frequently male (53% vs. 27%; p = 0.043), and there was a nonsignificant trend towards higher high-resolution CT (HRCT) score for bronchiectasis in responders (6.4 vs. 4.6; p = 0.053). In multivariate logistic regression analysis, age and male gender were independent predictors for improvement in this group. <\/jats:p><jats:p> Conclusion: The results of this retrospective study suggest that neomacrolides may be useful as an add-on therapy in patients with severe asthma and\/or bronchiectasis. Older age may predict good response in patients with severe asthma, whereas older age, male gender and a higher HRCT score for bronchiectasis may predict therapeutic response in patients with bronchiectasis only. Prospective controlled trials of neomacrolides in patients with severe asthma are needed to confirm these observations. <\/jats:p>","DOI":"10.1177\/1753465811406771","type":"journal-article","created":{"date-parts":[[2011,9,3]],"date-time":"2011-09-03T01:20:16Z","timestamp":1315012816000},"page":"377-386","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Neomacrolides in the treatment of patients with severe asthma and\/or bronchiectasis: a retrospective observational study"],"prefix":"10.1177","volume":"5","author":[{"given":"Mathieu","family":"Coeman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"van Durme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fre","family":"Bauters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Deschepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingel","family":"Demedts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Smeets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Joos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Brusselle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"bibr1-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62409-X"},{"key":"bibr2-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.ats9-00"},{"key":"bibr3-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00004904"},{"key":"bibr4-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2779"},{"key":"bibr5-1753465811406771","first-page":"37","volume":"65","author":"Ball B.D.","year":"1990","journal-title":"Ann Allergy"},{"key":"bibr6-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027992"},{"key":"bibr7-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D634"},{"key":"bibr8-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"bibr9-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.073429"},{"key":"bibr10-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-9-48"},{"key":"bibr11-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00042208"},{"key":"bibr12-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01321-8"},{"key":"bibr13-1753465811406771","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504020-00005"},{"key":"bibr14-1753465811406771","first-page":"540","volume":"59","author":"Davies G.","year":"2004","journal-title":"Thorax"},{"key":"bibr15-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2004.12.005"},{"key":"bibr16-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70175-2"},{"key":"bibr17-1753465811406771","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.08.001"},{"key":"bibr18-1753465811406771","unstructured":"Global Initiative for Asthma (GINA) (2006) Global Strategy for Asthma Management and Prevention. 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