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Clinical trials of treatment of latent TB conducted over several decades have demonstrated that preventive treatment can reduce the risk of developing active TB up to 90%. Although 9 months of daily, self-administered isoniazid has been the most widely used and recommended regimen for the treatment of latent infection, other regimens such as 3 months of daily isoniazid and rifampin, or 4 months of daily rifampin alone have also been recommended and used. Most recently, a 12-dose regimen of once-weekly isoniazid and rifapentine has been shown to be noninferior to 9 months of daily isoniazid in a large and well conducted clinical trial. Adoption of such a regimen on a large scale could have significant implications for TB elimination efforts. <\/jats:p>","DOI":"10.1177\/1753465813503028","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T04:55:30Z","timestamp":1379739330000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Treatment of latent tuberculosis infection"],"prefix":"10.1177","volume":"7","author":[{"given":"Madhavi J.","family":"Parekh","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil W.","family":"Schluger","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, PH-8 East, Room 101, 622 West 168th Street, New York, NY 10032, 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