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Similarly, minimally invasive biomarkers have shown promise but also have limitations in the diagnosis of mesothelioma. In experienced centers, cytology and immunohistochemistry are now sufficient to diagnose the epithelioid subtype of mesothelioma, which can reduce the need for more invasive diagnostic investigations. Prognosis of MPM is modestly impacted by oncological treatments. Chemotherapy with cisplatin and pemetrexed is considered the standard of care, though the addition of bevacizumab to the platinum doublet may be the new standard of care. New targeted therapies have demonstrated some promise and are being addressed in clinical trials. This review focuses on the current data on the diagnostic and therapeutic issues of MPM. <\/jats:p>","DOI":"10.1177\/1753465816628800","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T11:36:52Z","timestamp":1455363412000},"page":"275-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Malignant pleural mesothelioma: an update on diagnosis and treatment options"],"prefix":"10.1177","volume":"10","author":[{"given":"Sanjana","family":"Kondola","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Manners","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, 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