{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:42:46Z","timestamp":1766731366229,"version":"3.41.2"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Omalizumab may modulate airway remodeling in severe asthma. Using forced expiratory volume in 1 second (FEV<jats:sub>1<\/jats:sub>) as a surrogate of airway remodeling, we aimed to investigate if an omalizumab add-on in severe allergic asthma may lead to a persistent reversal of airway obstruction and to evaluate the potential biomarkers of airway obstruction reversibility. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Data were collected before (T0) and after omalizumab add-on for 1\u2009year (T1, 32 patients), 2\u2009years (T2, 26 patients) and 4\u2009years (T4, 13 patients). All patients had baseline FEV<jats:sub>1<\/jats:sub> below 80 % predicted (60.5 \u00b1 12.5 %). After omalizumab, 18 patients showed FEV<jats:sub>1<\/jats:sub> normalization (reversible airway obstruction; RAO+) already at T1 (88.7 \u00b1 14.9 %, p &lt; 0.0001) that persisted up to T4 (83.2 \u00b1 7.9, p &lt; 0.01), while 14 patients (RAO\u2212) had FEV<jats:sub>1<\/jats:sub> persistently decreased, from T1 (65.2 \u00b1 8.4%, p &lt; 0.05) up to T4 (61.4 \u00b1 6.2%, not significant). Both groups had significant improvement of symptoms and exacerbations after omalizumab at T1, which persisted up to T4. The comparison between pretreatment characteristics of the two groups showed that RAO+ patients, had higher values of circulating eosinophils, exhaled nitric oxide (F<jats:sub>E<\/jats:sub>NO), prevalence of rhinitis and nasal polyps, need of oral corticosteroids, shorter asthma duration, higher FEV<jats:sub>1<\/jats:sub> and response to albuterol test. The optimal cut-off points predicting FEV<jats:sub>1<\/jats:sub> normalization after omalizumab add-on were 30.5 ppb for F<jats:sub>E<\/jats:sub>NO and 305 cells\/\u00b5l for eosinophils. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> This study suggests that omalizumab add-on contributes to the persistent reversal of airway obstruction in a consistent number of patients with severe allergic asthma, and this beneficial effect is predicted by elevated pretreatment F<jats:sub>E<\/jats:sub>NO and circulating eosinophils. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753466619841274","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T10:44:58Z","timestamp":1555670698000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Predictors of reversible airway obstruction with omalizumab in severe asthma: a real-life study"],"prefix":"10.1177","volume":"13","author":[{"given":"Paolo","family":"Solidoro","sequence":"first","affiliation":[{"name":"S.C. Pneumologia U, Azienda Ospedaliero Universitaria Citt\u00e0 della Salute e della Scienza, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Patrucco","sequence":"additional","affiliation":[{"name":"S.C. Pneumologia U, Azienda Ospedaliero Universitaria Citt\u00e0 della Salute e della Scienza, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"de Blasio","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Brussino","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Bellocchia","sequence":"additional","affiliation":[{"name":"S.C. Pneumologia U, Azienda Ospedaliero Universitaria Citt\u00e0 della Salute e della Scienza, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Dassetto","sequence":"additional","affiliation":[{"name":"S.C. Pneumologia U, Azienda Ospedaliero Universitaria Citt\u00e0 della Salute e della Scienza, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Pivetta","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Riccio","sequence":"additional","affiliation":[{"name":"Respiratory Diseases and Allergy Unit, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Heffler","sequence":"additional","affiliation":[{"name":"Personalised Medicine Clinic Asthma & Allergy, Humanitas University, Department of Biomedical Sciences, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Canonica","sequence":"additional","affiliation":[{"name":"Personalised Medicine Clinic Asthma & Allergy, Humanitas University, Department of Biomedical Sciences, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Rolla","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Bucca","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Corso Dogliotti 14 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,19]]},"reference":[{"key":"bibr1-1753466619841274","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"bibr2-1753466619841274","unstructured":"Global Initiative for Asthma. 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