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Spiolto<jats:sup>\u00ae<\/jats:sup> or Stiolto<jats:sup>\u00ae<\/jats:sup> is a fixed-dose combination (FDC) containing two long-acting bronchodilators, the long-acting muscarinic receptor antagonist tiotropium (TIO) and the long-acting \u03b22-adrenoceptor agonist olodaterol (OLO), formulated in the Respimat<jats:sup>\u00ae<\/jats:sup> Soft Mist\u2122 inhaler. A total of 13 large, multicentre studies of up to 52\u2009weeks\u2019 duration have documented its efficacy in more than 15,000 patients with COPD. TIO\/OLO 5\/5\u2009\u00b5g FDC significantly increases pulmonary function compared with placebo and its respective constituent mono-components TIO 5\u2009\u00b5g and OLO 5\u2009\u00b5g. TIO\/OLO 5\/5\u2009\u00b5g also results in statistically and clinically significant improvements in patient-reported outcomes, such as dyspnoea, use of rescue medication, and health status. Addition of OLO 5\u2009\u00b5g to TIO 5\u2009\u00b5g reduces the rate of moderate-to-severe exacerbations by approximately 10%. Compared with placebo and TIO 5\u2009\u00b5g, TIO\/OLO 5\/5\u2009\u00b5g significantly improves exercise capacity (e.g. endurance time) and physical activity, the latter increase being reached by a unique combination behavioural modification intervention, dual bronchodilatation and exercise training. Overall, the likelihood for patients to experience a clinically significant benefit is higher with TIO\/OLO 5\/5\u2009\u00b5g than with its constituent mono-components, which usually yield smaller improvements which do not always reach statistical significance, compared with baseline or placebo. This supports the early introduction of TIO\/OLO 5\/5\u2009\u00b5g in the management of patients with symptomatic COPD. <\/jats:p>","DOI":"10.1177\/1753466619843426","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T10:44:28Z","timestamp":1555670668000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The once-daily fixed-dose combination of olodaterol and tiotropium in the management of COPD: current evidence and future prospects"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-4940","authenticated-orcid":false,"given":"Eric","family":"Derom","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Ghent University Hospital, Ingang 12, Route 1404, Corneel Heymanslaan 10, B-9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy 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