{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:31:29Z","timestamp":1788229889939,"version":"build-2803163510"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korea Health Technology R & D Project through the Korea Health Industry Development Institute","award":["HC15C1507"],"award-info":[{"award-number":["HC15C1507"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> There are limited data regarding prolonged extracorporeal membrane oxygenation (ECMO) support, despite increase in ECMO use and duration in patients with respiratory failure. The objective of this study was to investigate the outcomes of severe acute respiratory failure patients supported with prolonged ECMO for more than 28\u2009days. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Between January 2012 and December 2015, all consecutive adult patients with severe acute respiratory failure who underwent ECMO for respiratory support at 16 tertiary or university-affiliated hospitals in South Korea were enrolled retrospectively. The patients were divided into two groups: short-term group defined as ECMO for \u2a7d28\u2009days and long-term group defined as ECMO for more than 28\u2009days. In-hospital and 6-month mortalities were compared between the two groups. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 487 patients received ECMO support for acute respiratory failure during the study period, and the median support duration was 8\u2009days (4\u201320\u2009days). Of these patients, 411 (84.4%) received ECMO support for \u2a7d28\u2009days (short-term group), and 76 (15.6%) received support for more than 28\u2009days (long-term group). The proportion of acute exacerbation of interstitial lung disease as a cause of respiratory failure was higher in the long-term group than in the short-term group (22.4% versus 7.5%, p\u2009&lt;\u20090.001), and the duration of mechanical ventilation before ECMO was longer (4\u2009days versus 1\u2009day, p\u2009&lt;\u20090.001). The hospital mortality rate (60.8% versus 69.7%, p\u2009=\u20090.141) and the 6-month mortality rate (66.2% versus 74.0%, p\u2009=\u20090.196) were not different between the two groups. ECMO support longer than 28\u2009days was not associated with hospital mortality in univariable and multivariable analyses. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Short- and long-term survival rates among patients receiving ECMO support for more than 28\u2009days for severe acute respiratory failure were not worse than those among patients receiving ECMO for 28\u2009days or less. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753466619848941","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T13:21:58Z","timestamp":1557926518000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical outcomes of patients receiving prolonged extracorporeal membrane oxygenation for respiratory support"],"prefix":"10.1177","volume":"13","author":[{"given":"Soo Jin","family":"Na","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Bum","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pusan National University Yangsan Hospital, Gyeongsangnam-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jae","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghoon","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-My","family":"Koo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Allergy Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Hospital, Jeollabuk-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-466X","authenticated-orcid":false,"given":"Youjin","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Ju","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, CHA Bundang Medical Center, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Dongguk University Ilsan Hospital, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Wan","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Gyeongsang National University Hospital, Gyeonsangnam-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Su","family":"Sim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-1772","authenticated-orcid":false,"given":"Kyeongman","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"bibr1-1753466619848941","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1103720"},{"key":"bibr2-1753466619848941","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000475"},{"key":"bibr3-1753466619848941","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12032"},{"key":"bibr4-1753466619848941","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182a9e341"},{"key":"bibr5-1753466619848941","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.71"},{"key":"bibr6-1753466619848941","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.08.003"},{"key":"bibr7-1753466619848941","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182904a52"},{"key":"bibr8-1753466619848941","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001176"},{"key":"bibr9-1753466619848941","first-page":"1341","volume":"40","author":"Camboni 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