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The phenomenon of a cytokine storm may be the central inducer of apoptosis of alveolar epithelial cells, which leads to rapid progression in severe group patients. Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNF\u03b1, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. <\/jats:p><jats:p> The reviews of this paper are available via the supplemental material section. <\/jats:p>","DOI":"10.1177\/1753466620926800","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T11:32:34Z","timestamp":1590060754000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["TNF\u03b1 inhibitor may be effective for severe COVID-19: learning from toxic epidermal necrolysis"],"prefix":"10.1177","volume":"14","author":[{"given":"Xue-Yan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Xi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-5538","authenticated-orcid":false,"given":"Xiao-Yong","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd, Hangzhou, Zhejiang 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"bibr1-1753466620926800","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25678"},{"key":"bibr2-1753466620926800","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.009"},{"key":"bibr3-1753466620926800","unstructured":"WHO. 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