{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:10:00Z","timestamp":1782781800224,"version":"3.54.5"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Talaromyces marneffei, also named Penicillium marneffei, is an opportunistic pathogen that can cause systemic or limited infection in human beings. This infection is especially common in human immunodeficiency virus (HIV)-infected hosts; however, it has also been recently reported in HIV-negative hosts. Here, we report a very rarely seen case of T. marneffei pulmonary infection in a non-HIV-infected patient with signal transducer and activator of transcription 3 ( STAT3) mutation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation:<\/jats:title><jats:p> A 34-year-old woman was admitted to our hospital for uncontrollable nonproductive cough and dyspnea with exercise. She had been immunocompromised since infancy. Computerized tomography scan showed multiple ground glass opacities with multiple bullae in both lungs. Next generation sequencing (NGS) of the bronchoalveolar lavage fluid identified T. marneffei nucleotide sequences. Culture of bronchoscopy specimens further verified the results. The patient was HIV negative, and blood gene detection indicated STAT3 mutation. To date, following the application of itraconazole, the patient has recovered satisfactorily. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In clinical practice, T. marneffei infection among HIV-negative individuals is relatively rare, and we found that patients who are congenitally immunocompromised due to STAT3 mutation may be potential hosts. Early diagnosis and timely treatment are expected to improve the prognosis of T. marneffei infection. NGS is a powerful technique that may play an important role in this progress. The reviews of this paper are available via the supplemental material section. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753466620929225","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T05:19:37Z","timestamp":1591075177000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Rapid and precise diagnosis of <i>T. marneffei<\/i> pulmonary infection in a HIV-negative patient with autosomal-dominant <i>STAT3<\/i> mutation: a case report"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-0263","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, #261 Huansha Road, Hangzhou, 310006, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Liangzhu Hospital of Yuhang, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liusheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medical, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"bibr1-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.95-110.2006"},{"key":"bibr2-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/60.2.259"},{"key":"bibr3-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2016.18"},{"key":"bibr4-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00053-10"},{"key":"bibr5-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.051"},{"key":"bibr6-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100102"},{"key":"bibr7-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1202117"},{"key":"bibr8-1753466620929225","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00130"},{"key":"bibr9-1753466620929225","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00038"},{"key":"bibr10-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.01.026"},{"key":"bibr11-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3968-5"},{"key":"bibr12-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3276-5"},{"key":"bibr13-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-014-9787-8"},{"key":"bibr14-1753466620929225","unstructured":"Panel 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Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the centers for disease control and prevention, the national institutes of health, and the HIV medicine association of the infectious diseases society of America, https:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/adult_oi.pdf (accessed 7 March 2018)."},{"key":"bibr15-1753466620929225","doi-asserted-by":"crossref","first-page":"e0130376","DOI":"10.1371\/journal.pone.0130376","volume":"10","author":"Zheng J","year":"2015","journal-title":"PLoS One"},{"key":"bibr16-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-464"},{"key":"bibr17-1753466620929225","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1243-y"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753466620929225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753466620929225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753466620929225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T16:38:13Z","timestamp":1740847093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753466620929225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":17,"alternative-id":["10.1177\/1753466620929225"],"URL":"https:\/\/doi.org\/10.1177\/1753466620929225","relation":{},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1753466620929225"}}