{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:04:29Z","timestamp":1790777069358,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Current availability of several biologic treatments for severe asthma makes it possible to choose the most appropriate for each patient. Sometimes a good percentage of patients with severe asthma may be eligible for biologics that target either the allergic phenotype or the eosinophilic one, but not all respond to that selected as first choice. The aim of our real-life study was to assess whether, for patients with severe eosinophilic allergic asthma, not previously controlled by the anti-IgE omalizumab, the shift to another biologic targeting interleukin-5, such as mepolizumab, may represent a good therapeutic choice. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A total of 41 consecutive patients with severe, persistent allergic, eosinophilic asthma, uncontrolled despite treatment with omalizumab, were enrolled in seven certified Clinical Respiratory Units of Southern Italy (Catania, Catanzaro, Foggia, Bari, Palermo, and two University Respiratory Units of Naples) and shifted to mepolizumab without a wash-out period. Data at baseline, after at least 12\u2009months of therapy with omalizumab, and after at least 12\u2009months of treatment with mepolizumab were collected. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> After at least 12\u2009months of therapy with mepolizumab, patients experienced a significant decrease in the number of exacerbations\/year (5.8\u2009\u00b1\u20091.8 versus 0.7\u2009\u00b1\u20090.9, p\u2009&lt;\u20090.0001), an increment of asthma control test score (12\u2009\u00b1\u20092.7 versus 21.9\u2009\u00b1\u20092.7, p\u2009&lt;\u20090.0001), an increase in pre-bronchodilator forced expiratory volume in 1\u2009s (1.56\u2009\u00b1\u20090.45\u2009l versus 1.86\u2009\u00b1\u20090.52\u2009l, p\u2009&lt;\u20090.0001), and a reduction of blood eosinophils (584\u2009\u00b1\u2009196 cells\/\u00b5l versus 82\u2009\u00b1\u200956 cells\/\u00b5l, p\u2009&lt;\u20090.0001). The percentage of patients who were dependent on corticosteroids significantly decreased from 46% at baseline to 5% during treatment with mepolizumab. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Results of our real-life multicentric experience confirms that the shift to mepolizumab could be a good therapeutic strategy in severe eosinophilic allergic asthma not previously controlled by omalizumab. The reviews of this paper are available via the supplemental material section. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753466620929231","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:56:32Z","timestamp":1591073792000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Switching from omalizumab to mepolizumab: real-life experience from Southern Italy"],"prefix":"10.1177","volume":"14","author":[{"given":"Giovanna Elisiana","family":"Carpagnano","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Respiratory Disease, University \u201cAldo Moro\u201d of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Pelaia","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Respiratory Disease, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D\u2019Amato","sequence":"additional","affiliation":[{"name":"Division of Pneumology, Department of Respiratory Diseases, University of Naples Federico II, AORN dei Colli-Monaldi Hospital, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Crimi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialistic Medicine, Section of Respiratory Diseases, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Scichilone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pneumology, Physiology and Nutrition, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-077X","authenticated-orcid":false,"given":"Giulia","family":"Scioscia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Institute of Respiratory Disease, University of Foggia, Policlinico Riuniti di Foggia - Viale Pinto, 1, 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onofrio","family":"Resta","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Respiratory Disease, University \u201cAldo Moro\u201d of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, Section of Respiratory Disease, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-8913","authenticated-orcid":false,"given":"Girolamo","family":"Pelaia","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Respiratory Disease, University \u201cMagna Gr\u00e6cia\u201d of Catanzaro, Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Maria Irene","family":"Quarato","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, University of Foggia, Policlinico Riuniti di Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Foschino Barbaro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, University of Foggia, Policlinico Riuniti di Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"bibr1-1753466620929231","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.197046"},{"key":"bibr2-1753466620929231","unstructured":"Global Initiative for Asthma. 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