{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:40:20Z","timestamp":1789756820038,"version":"4.0.1"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HC19C0318"],"award-info":[{"award-number":["HC19C0318"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019M3E5D1A01069363"],"award-info":[{"award-number":["2019M3E5D1A01069363"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Long-term corticosteroid (CS) use is associated with increased mortality in patients with asthma, and comorbid bronchiectasis is also associated with frequent asthma exacerbation and increased healthcare use. However, there is limited information on whether bronchiectasis further increases mortality in patients with CS-dependent asthma. This study examined the impact of bronchiectasis on mortality in patients with CS-dependent asthma. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A retrospective cohort of patients with CS-dependent asthma \u2a7e18\u2009years old was established using records from the Korean National Health Insurance Service database from 2005 to 2015. Patients with CS-dependent asthma with and without bronchiectasis were matched by age, sex, type of insurance, and Charlson comorbidity index. We evaluated the hazard ratio (HR) for all-cause mortality in patients with bronchiectasis compared with those without bronchiectasis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The study cohort included 754 patients with CS-dependent asthma with bronchiectasis and 3016 patients with CS-dependent asthma without bronchiectasis. Patients with CS-dependent asthma with bronchiectasis had a higher all-cause mortality than those without bronchiectasis (8429\/100,000 versus 6962\/100,000 person-years, p\u2009&lt;\u20090.001). The adjusted HR for mortality in patients with CS-dependent asthma with bronchiectasis relative to those without bronchiectasis was 1.33 (95% confidence interval, 1.18\u20131.50), and the association was primarily significant for respiratory diseases (subdistribution HR\u2009=\u20091.65, 95% confidence interval, 1.42\u20131.92). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Bronchiectasis further increases all-cause mortality in patients with CS-dependent asthma, a trend that was especially associated with respiratory diseases including chronic obstructive pulmonary disease. Strategies to improve treatment outcomes in patients with CS-dependent asthma with bronchiectasis are urgently needed to improve long-term survival. The reviews of this paper are available via the supplemental material section. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753466620963030","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T03:44:03Z","timestamp":1602819843000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Bronchiectasis and increased mortality in patients with corticosteroid-dependent severe asthma: a nationwide population study"],"prefix":"10.1177","volume":"14","author":[{"given":"Hayoung","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea"},{"name":"Lung Research Institute, Hallym University College of Medicine, Chuncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiin","family":"Ryu","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Won","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Joo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-4444","authenticated-orcid":false,"given":"Sang-Heon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"bibr1-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"bibr2-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.042"},{"key":"bibr3-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0719-x"},{"key":"bibr4-1753466620963030","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2020.12.6.910"},{"key":"bibr5-1753466620963030","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2019.11.1.43"},{"key":"bibr6-1753466620963030","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2018.10.3.225"},{"key":"bibr7-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01163-2019"},{"key":"bibr8-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00804-2019"},{"key":"bibr9-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03981.x"},{"key":"bibr10-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/361071"},{"key":"bibr11-1753466620963030","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1004683"},{"key":"bibr12-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000492"},{"key":"bibr13-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.02.016"},{"key":"bibr14-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1579832"},{"key":"bibr15-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01862-2015"},{"key":"bibr16-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.04.022"},{"key":"bibr17-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.09.009."},{"key":"bibr18-1753466620963030","first-page":"799","volume":"46","author":"Cheol Seong S","year":"2017","journal-title":"Int J Epidemiol"},{"key":"bibr19-1753466620963030","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.05.95"},{"key":"bibr20-1753466620963030","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.08.110"},{"key":"bibr21-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1111\/all.12256"},{"key":"bibr22-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.07.046"},{"key":"bibr23-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.031"},{"key":"bibr24-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00194-2019"},{"key":"bibr25-1753466620963030","volume-title":"Technical report series no. 56, computerized matching of cases to controls","author":"Bergstralh E","year":"1995"},{"key":"bibr26-1753466620963030","doi-asserted-by":"publisher","DOI":"10.4300\/JGME-D-12-00156.1"},{"key":"bibr27-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"bibr28-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009000800010"},{"key":"bibr29-1753466620963030","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.09.36"},{"key":"bibr30-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12653"},{"key":"bibr31-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0042-3"},{"key":"bibr32-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70005-5"},{"key":"bibr33-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00629-2017"},{"key":"bibr34-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1575OC"},{"key":"bibr35-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205328"},{"key":"bibr36-1753466620963030","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01333-2019"},{"key":"bibr37-1753466620963030","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S196200"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753466620963030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753466620963030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753466620963030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T10:14:07Z","timestamp":1738059247000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753466620963030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":37,"alternative-id":["10.1177\/1753466620963030"],"URL":"https:\/\/doi.org\/10.1177\/1753466620963030","relation":{},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1753466620963030"}}