{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:32:01Z","timestamp":1791847921563,"version":"4.3.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Use of noninvasive ventilation (NIV) in patients with moderate to severe ARDS is controversial. We aimed to use HACOR (combination of heart rate, acidosis, consciousness, oxygenation and respiratory rate) score to comprehensively assess the efficacy of NIV in ARDS patients with PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      \u2004\u2a7d\u2004150\u2009mmHg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Secondary analysis was performed using the data collected from two databases. We screened the ARDS patients who used NIV as a first-line therapy. Patients with PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      \u2004\u2a7d\u2004150\u2009mmHg were enrolled. NIV failure was defined as requirement of intubation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 224 moderate to severe ARDS patients who used NIV as a first-line therapy were enrolled. Of them, 125 patients (56%) experienced NIV failure and received intubation. Among the intubated patients, the survivor had shorter time from initiation of NIV to intubation than nonsurvivors (median 10 vs 22 h, p \u2009&lt;\u20090.01). The median differences of HACOR score before and 1\u20132\u2009h of NIV were 1 point (interquartile range: 0\u20133). We defined the patients with \u25b3HACOR &gt;1 as responders (n \u2009=\u2009102) and the rest to non-responders (n \u2009=\u2009122). Compared to non-responders, the responders had higher HACOR score before NIV. However, the HACOR score was lower in the responders than non-responders after 1\u20132 h, 12 h, and 24\u2009h of NIV. The responders also had lower NIV failure rate (36% vs 72%, p \u2009&lt;\u20090.01) and lower 28-day mortality (32% vs 47%, p \u2009=\u20090.04) than non-responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>NIV failure was high among patients with moderate to severe ARDS. Delayed intubation is associated with increased mortality. The reduction of HACOR score after 1\u20132\u2009h of NIV can identify the patients who respond well to NIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666221081042","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T07:58:03Z","timestamp":1645689483000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Early assessment of the efficacy of noninvasive ventilation tested by HACOR score to avoid delayed intubation in patients with moderate to severe ARDS"],"prefix":"10.1177","volume":"16","author":[{"given":"Linfu","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Bishan Hospital of Chongqing, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-0117","authenticated-orcid":false,"given":"Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Yuzhong District, Chongqing 400016, Sichuan, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"bibr1-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2011.05.012"},{"key":"bibr2-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201606-1306OC"},{"key":"bibr3-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-226OC"},{"key":"bibr4-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.9524"},{"key":"bibr5-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0324-1"},{"key":"bibr6-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1186\/cc13103"},{"key":"bibr7-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.01.018"},{"key":"bibr8-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4601-3"},{"key":"bibr9-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.08.008"},{"key":"bibr10-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106550"},{"key":"bibr11-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202102-161OC"},{"key":"bibr12-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4411-7"},{"key":"bibr13-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000254"},{"key":"bibr14-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.06.010"},{"key":"bibr15-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3693-5"},{"key":"bibr16-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2475-6"},{"key":"bibr17-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06459-2"},{"key":"bibr18-17534666221081042","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-072OC"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666221081042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666221081042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666221081042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T21:53:28Z","timestamp":1740866008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666221081042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":18,"alternative-id":["10.1177\/17534666221081042"],"URL":"https:\/\/doi.org\/10.1177\/17534666221081042","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666221081042\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221081042\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221081042\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221081042\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221081042\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221081042\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"17534666221081042"}}