{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:31:19Z","timestamp":1791973879101,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Incubative Project for Innovation Team of GMU","award":["2017-159"],"award-info":[{"award-number":["2017-159"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770098"],"award-info":[{"award-number":["81770098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The data in regard of the clinical characteristics and diagnosis of somatic cough syndrome in adults were limited. The aim of this study was to fill that gap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective analysis of patients with somatic cough syndrome. We described clinical characteristics of adult patients with somatic cough syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-three somatic cough syndrome patients were identified in 543 adult patients with chronic cough. Psychiatric disorder of these patients was identified as anxiety ( n\u2009=\u20098), obsessive-compulsive ( n\u2009=\u20097), somatoform ( n\u2009=\u20096), depression ( n\u2009=\u20093), and cognitive bias ( n\u2009=\u20091). Twelve patients showed abnormal results of investigations related with common causes of chronic cough, including gastroesophageal reflux, sputum eosinophilia, bronchial hyper-responsiveness, or signs of sinusitis but did not respond to the treatments directed to those conditions. All these patients were ever misdiagnosed as other causes of chronic cough. Compared to 520 non-somatic cough syndrome patients, patients with somatic cough syndrome were younger (32 (29.0\u201343.0) vs 42.0 (32.0\u201355.0) years, p\u2009=\u20090.013), longer disease duration (48.0 (19.5\u2013102.0) vs 24.0 (9.0\u201372.0) months, p\u2009=\u20090.037), more common in dry cough (100% vs 57.6%, p\u2009&lt;\u20090.001), and lower proportion of nocturnal cough (13.0% vs 40.2%, p\u2009=\u20090.009). Common cold (60.9%) was the most common initial trigger of cough and itchy throat (60.9%) was the most common accompanying symptom in patients with somatic cough syndrome. Notably, there were similar distribution in cough triggers and accompanying symptoms between two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In spite of much higher proportion of dry cough and smaller proportion of nocturnal cough, adult patients with somatic cough syndrome show similar clinical characteristics with other chronic cough patients, in regard of cough triggers, accompanying symptoms as well as abnormal results of investigations, which should be an important reason for misdiagnosis of somatic cough syndrome. Psychiatric disorder should be addressed in clinical management of chronic cough.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666221092993","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T08:12:09Z","timestamp":1661155929000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical characteristics in adult patients with somatic cough syndrome"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-7296","authenticated-orcid":false,"given":"Kefang","family":"Lai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510210, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-4332","authenticated-orcid":false,"given":"Wenzhi","family":"Zhan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xing","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-ping","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Psychology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-man","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-yu","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Shan","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"bibr1-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00218714"},{"key":"bibr2-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0441"},{"key":"bibr3-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60595-4"},{"key":"bibr4-17534666221092993","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-2671"},{"key":"bibr5-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1_suppl.174S"},{"key":"bibr6-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-011-9317-0"},{"key":"bibr7-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-015-0180-0"},{"key":"bibr8-17534666221092993","first-page":"27","volume":"23","author":"Mastrovich JD","year":"2002","journal-title":"Allergy Asthma Proc"},{"key":"bibr9-17534666221092993","doi-asserted-by":"publisher","DOI":"10.2190\/9CTG-8FR7-FBQJ-181V"},{"key":"bibr10-17534666221092993","first-page":"483","volume":"48","author":"Gay M","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"bibr11-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.06.066"},{"key":"bibr12-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07071246"},{"key":"bibr13-17534666221092993","first-page":"43","volume":"24","author":"Berman BA","year":"1966","journal-title":"Ann Allergy"},{"key":"bibr14-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.10.041"},{"key":"bibr15-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23948"},{"key":"bibr16-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01060.x"},{"key":"bibr17-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0795"},{"key":"bibr18-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0423"},{"key":"bibr19-17534666221092993","volume":"351","author":"Gibson PG","year":"2015","journal-title":"BMJ"},{"key":"bibr20-17534666221092993","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2019.11.5.622"},{"key":"bibr21-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00793-2020"},{"key":"bibr22-17534666221092993","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2020-icc-007"},{"key":"bibr23-17534666221092993","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2017.9.5.394"},{"key":"bibr24-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02203-2018"},{"key":"bibr25-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-2-11"},{"key":"bibr26-17534666221092993","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00140803"},{"key":"bibr27-17534666221092993","first-page":"579","volume":"67","author":"Lokshin B","year":"1991","journal-title":"Ann Allergy"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666221092993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666221092993","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666221092993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T06:03:48Z","timestamp":1740981828000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666221092993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":27,"alternative-id":["10.1177\/17534666221092993"],"URL":"https:\/\/doi.org\/10.1177\/17534666221092993","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666221092993\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221092993\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221092993\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221092993\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221092993\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666221092993\/v2\/review1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"17534666221092993"}}