{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:35:31Z","timestamp":1786793731220,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The SABINA CHINA study aimed to determine prescription data for asthma medication with a focus on SABA and ICS in a representative population of patients with asthma in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>SABINA China was a multicentre, observational, cross-sectional study with data collected retrospectively from a convenience sample of 25 tertiary centres across China. Patients (age\u2009\u2a7e\u200912\u2009years) with \u2a7e3 consultations\/year were enrolled. Data were collected on clinical characteristics, asthma severity, and symptom control (as per GINA 2017), treatment and history of severe exacerbations over the past year. SABA over-prescription was defined as \u2a7e3 SABA canisters\/year. Descriptive statistics are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Between March and August 2020, 498 patients were included in the outcome analysis. Mean (SD) age was 48.7 (15.0) years, 57.9% were female and 91% had moderate-to-severe asthma ( n\u2009=\u2009453). Overall, 12.5% ( n\u2009=\u200962) and 26.4% ( n\u2009=\u2009131) of patients had uncontrolled and partly controlled asthma, respectively. SABA add-on was prescribed to 20.3% ( n\u2009=\u2009101) of patients; one patient with moderate-to-severe asthma was prescribed SABA-alone. SABA over-prescription in the overall population was 4.0% ( n\u2009=\u200920; all with moderate-to-severe asthma) and 19.8% (20\/101) among those prescribed SABA add-on. In the mild asthma group, 50% ( n\u2009=\u200922) were prescribed ICS\/LABA and 43.2% ( n\u2009=\u200919) were prescribed LTRA. Among those with moderate-to-severe asthma, 97.4% ( n\u2009=\u2009441) were prescribed ICS\/LABA and 55.0% ( n\u2009=\u2009249) were prescribed LTRA. Approximately 30% of patients ( n\u2009=\u2009149) experienced \u2a7e1% and 6.6% ( n\u2009=\u200933) \u2a7e3 severe exacerbations in the preceding year; mean annual number of severe exacerbation\/patient was 0.6 (1.2). Among those prescribed SABA add-on, ICS\/LABA and LTRA (non-mutually exclusive groups due to overlapping prescriptions), 54.5%, 29.9%, and 35.3% had \u2a7e1 severe exacerbations, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among patients with predominantly moderate-to-severe asthma managed in tertiary care and were prescribed SABA, 1 in 5 received \u2a7e3 canisters\/year. Fewer patients who received ICS\/LABA prescriptions experienced annual exacerbations than those prescribed SABA add-on.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666221115054","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T02:44:46Z","timestamp":1662432286000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Short-acting beta-2 agonist prescription patterns and clinical outcomes in Chinese patients with asthma: an observational study in mainland China for the SABINA programme"],"prefix":"10.1177","volume":"16","author":[{"given":"Wuping","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqing","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai Putuo District People\u2019s Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Inner Mongolia Autonomous Region People\u2019s Hospital, Hohhot, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-7296","authenticated-orcid":false,"given":"Kefang","family":"Lai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huapeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Beekman","sequence":"additional","affiliation":[{"name":"International Medical Respiratory & Immunology, AstraZeneca Netherlands, The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-9524","authenticated-orcid":false,"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"bibr1-17534666221115054","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31147-X"},{"key":"bibr2-17534666221115054","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.30"},{"key":"bibr3-17534666221115054","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.5.1407"},{"key":"bibr4-17534666221115054","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05779-8"},{"key":"bibr5-17534666221115054","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention, https:\/\/ginasthma.org\/archived-reports\/ (2018, accessed 30 March 2020)."},{"key":"bibr6-17534666221115054","unstructured":"Global Initiative for Asthma. 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