{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:21:07Z","timestamp":1790014867473,"version":"4.0.1"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Pulmonary arterial hypertension is a progressive haemodynamic disease with high morbidity and mortality. Of the different treatments available, the prostacyclin analogues are the drugs of choice for high-risk patients, with treprostinil being the most commonly used drug in Argentina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>The objective of this study is to perform a retrospective evaluation of the efficacy and safety of subcutaneous treprostinil in regular clinical practice in Argentina in 51 patients with pulmonary arterial hypertension after 12\u2009months of follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results showed that treatment with subcutaneous treprostinil is associated with a significant improvement in different clinical efficacy parameters: 65% reduction in advanced functional class ( p\u2009&lt;\u20090.0001), 130-m increase in the 6-min walk test ( p\u2009&lt;\u20090.0001), 65% reduction in the pro B-type natriuretic peptide value (\u2013531\u2009pg\/dL; p\u2009&lt;\u20090.0001), significant reduction of 15.7% in pulmonary vascular resistance [\u20131.3\u2009wood units (WU); p\u2009&lt;\u20090.0001], improved cardiac index with an increase of 16.7% (+0.4\u2009L\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; p\u2009=\u20090.002), as well as a high survival rate (92%) and a 44% incidence of combined events (mortality, heart failure, syncope and\/or lung transplantation), without a significant increase in previously reported adverse events. The risk stratification evaluation according to ESC\/ERS guidelines showed a significant decrease in the proportion of patients at high risk after the treatment period ( p\u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These real-world results corroborate the efficacy and safety of subcutaneous treprostinil, even at high doses, and open up the possibility of improving its current use in clinical practice as a first-line therapy, especially in high-risk patient profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666221132735","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T06:44:04Z","timestamp":1667198644000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Real-world evidence of subcutaneous treprostinil use in pulmonary arterial hypertension in Argentina"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-8666","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Lescano","sequence":"first","affiliation":[{"name":"Centro Gallego, Buenos Aires Av. Belgrano 2199, C1094 AAD Buenos Aires, Argentina"},{"name":"Cardiology Department Sanatorio Trinidad Quilmes, Av. Carlos Pellegrini 431, B1878 Quilmes, Provincia de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Giacommi","sequence":"additional","affiliation":[{"name":"Hospital Interzonal de Agudos \u2018Dr. Oscar E. Allende\u2019, Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian E.","family":"Botta","sequence":"additional","affiliation":[{"name":"Department of Heart Failure and Pulmonary Arterial Hypertension, Sanatorio Privado San Ger\u00f3nimo, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Soricetti","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Carlos G. Durand, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Cardiology, Area of Heart Failure, Pulmonary Hypertension and Transplantation, Hospital Italiano de Mendoza, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Vargas Mielles","sequence":"additional","affiliation":[{"name":"Cardiology Department, Sanatorio Trinidad Quilmes, Quilmes, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabi\u00e1n","family":"Diez","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Rosario, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"bibr1-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"bibr2-17534666221132735","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"bibr3-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200302000-00019"},{"key":"bibr4-17534666221132735","first-page":"177","volume":"69","author":"Gali\u00e8 N","year":"2016","journal-title":"Rev Espa\u00f1ola Cardiol (English Ed)"},{"key":"bibr5-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.6.1636"},{"key":"bibr6-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2.2.183"},{"key":"bibr7-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"bibr8-17534666221132735","volume-title":"Hipertensi\u00f3n Pulmonar","author":"Lescano A","year":"2017"},{"key":"bibr9-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-12"},{"key":"bibr10-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp022"},{"key":"bibr11-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0300"},{"key":"bibr12-17534666221132735","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1118152"},{"key":"bibr13-17534666221132735","unstructured":"Talavera ML, C\u00e1neva JO, Favaloro LE, et al. Hipertensi\u00f3n arterial pulmonar: Registro de un centro de referencia en Argentina. 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