{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:06:24Z","timestamp":1772165184582,"version":"3.50.1"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Sarcoidosis is a multisystem disease with an unknown etiology and is characterized by the formation of noncaseating granulomas in the affected organs. We present the case of a 69-year-old male Japanese patient with bilateral hilar lymphadenopathy on chest radiographs for more than 10\u2009years, left without further investigation. The patient reported no clinical symptoms. Chest computed tomography revealed ground-glass opacities and reticular shadows in both lungs, along with bilateral hilar and mediastinal lymphadenopathy. Lymphocytosis was observed in bronchoalveolar lavage fluid. Pathological examination of transbronchial lung biopsy revealed noncaseating, epithelioid granulomas congruous with sarcoidosis, together with other findings. There were no abnormalities on electrocardiogram, echocardiogram, and ophthalmic examination.<\/jats:p>\n                  <jats:p>For progressive dyspnea on exertion, systemic corticosteroid therapy with oral prednisolone (25\u2009mg\/day) was initiated in 2017 and gradually tapered. Despite this intervention, the decline in forced vital capacity (FVC) was accelerated. Three years later, the patient noticed swelling in his right wrist. Further investigation revealed elevated anti-cyclic citrullinated peptide antibodies and absence of noncaseating epithelioid granuloma on surgical biopsy, leading to the diagnosis of rheumatoid arthritis (RA). Thereafter, the anti-fibrotic agent nintedanib was initiated, because interstitial lung disease (ILD) was considered to have converted into a progressive fibrosing phenotype (PF-ILD) with overlapping RA-associated lung involvement. With treatment, the progression of decline in FVC was slowed, although home oxygen therapy was introduced.<\/jats:p>","DOI":"10.1177\/17534666231158279","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T03:32:09Z","timestamp":1678073529000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary sarcoidosis complicated by rheumatoid arthritis in a patient presenting with progressive fibrosing interstitial lung disease and treated with nintedanib: a case report and literature review"],"prefix":"10.1177","volume":"17","author":[{"given":"Ayana","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Nippon Medical School Musashikosugi Hospital, Kawasaki-shi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-9548","authenticated-orcid":false,"given":"Koichiro","family":"Kamio","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugi-machi, Nakahara-ku, Kawasaki-shi 211-8533, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Takeno","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology, Nippon Medical School Musashikosugi Hospital, Kawasaki-shi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namiko","family":"Taniuchi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Nippon Medical School Musashikosugi Hospital, Kawasaki-shi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junpei","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Nippon Medical School Musashikosugi Hospital, Kawasaki-shi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Nippon Medical School Musashikosugi Hospital, Kawasaki-shi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Seike","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Gemma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arata","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Nippon Medical School Musashikosugi Hospital, Kawasaki-shi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"bibr1-17534666231158279","volume-title":"Sarcoidosis","author":"Bokhari SRA","year":"2021"},{"key":"bibr2-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000077"},{"key":"bibr3-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1177\/2040622318790197"},{"key":"bibr4-17534666231158279","first-page":"37","volume":"77","author":"Jeny F","year":"2020","journal-title":"Respir Med Res"},{"key":"bibr5-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713130"},{"key":"bibr6-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2012.04.004"},{"key":"bibr7-17534666231158279","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.565420"},{"key":"bibr8-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283642a7a"},{"key":"bibr9-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000489"},{"key":"bibr10-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1615054"},{"key":"bibr11-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X13511197"},{"key":"bibr12-17534666231158279","volume-title":"Rheumatoid arthritis","author":"Chauhan K","year":"2021"},{"key":"bibr13-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00075307"},{"key":"bibr14-17534666231158279","first-page":"158","volume":"74","author":"Assayag D","year":"2014","journal-title":"Medicina"},{"key":"bibr15-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2005230"},{"key":"bibr16-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000712"},{"key":"bibr17-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1647040"},{"key":"bibr18-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908681"},{"key":"bibr19-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00152106"},{"key":"bibr20-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.3.604"},{"key":"bibr21-17534666231158279","first-page":"526","volume":"11","author":"Fallahi S","year":"1984","journal-title":"J Rheumatol"},{"key":"bibr22-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030472"},{"key":"bibr23-17534666231158279","first-page":"381","volume":"45","author":"Kasumoto H","year":"2003","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"bibr24-17534666231158279","first-page":"164","volume":"27","author":"Leo G","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"bibr25-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-208803."},{"key":"bibr26-17534666231158279","first-page":"85","volume":"41","author":"Yutani Y","year":"1995","journal-title":"Osaka City Med J"},{"key":"bibr27-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0594-1"},{"key":"bibr28-17534666231158279","first-page":"358567","volume":"2014","author":"Thongpooswan S","year":"2014","journal-title":"Case Rep Rheumatol"},{"key":"bibr29-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1577-1"},{"key":"bibr30-17534666231158279","first-page":"99","volume":"25","author":"Almod\u00f3var R","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"bibr31-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0193-5"},{"key":"bibr32-17534666231158279","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4275-19"},{"key":"bibr33-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu195"},{"key":"bibr34-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel202"},{"key":"bibr35-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1002\/art.38201"},{"key":"bibr36-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016839"},{"key":"bibr37-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211138"},{"key":"bibr38-17534666231158279","first-page":"149","volume":"16","author":"Hunninghake GW","year":"1999","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"bibr39-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2019.10.001"},{"key":"bibr40-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.1.185"},{"key":"bibr41-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.08.008"},{"key":"bibr42-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.539"},{"key":"bibr43-17534666231158279","first-page":"103","volume":"30","author":"Song JW","year":"2013","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"bibr44-17534666231158279","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402584"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666231158279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666231158279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666231158279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T04:31:52Z","timestamp":1740889912000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666231158279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":44,"alternative-id":["10.1177\/17534666231158279"],"URL":"https:\/\/doi.org\/10.1177\/17534666231158279","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666231158279\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231158279\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231158279\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231158279\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231158279\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231158279\/v2\/review1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"17534666231158279"}}