{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:24:27Z","timestamp":1791228267332,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81900032"],"award-info":[{"award-number":["No.81900032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Science and Technology Plan project","award":["No. 202102010362"],"award-info":[{"award-number":["No. 202102010362"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A few studies have reported the medium-sized and small airway morphological abnormalities of bronchiolitis. Whether spirometry or impulse oscillometry (IOS) is correlated with airway remodeling of bronchiolitis remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Aiming to demonstrate the airway morphological abnormalities of bronchiolitis obliterans (BO) and diffuse panbronchiolitis (DPB) assessed by endobronchial optical coherence tomography (EB-OCT), and elucidate whether spirometric and IOS parameters have correlation with the airway remodeling of bronchiolitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We recruited 18 patients with bronchiolitis (BO, n\u2009=\u20099; DPB, n\u2009=\u20099) and 17 control subjects. Assessments of clinical features, St. George\u2019s respiratory questionnaire (SGRQ), chest computed tomography (CT), spirometry, IOS, and EB-OCT were performed in all enrolled subjects. The correlation between EB-OCT and lung function parameters was studied and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The magnitude of abnormalities of spirometric and IOS parameters was significantly greater in patients with bronchiolitis than that in control subjects ( p\u2009&lt;\u20090.05). Patients with BO had notably lower forced expiratory volume in 1\u2009s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ), forced vital capacity (FVC), FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC, maximal mid-expiratory flow (MMEF)% pred and higher resonant frequency (Fres), and area of reactance (AX) than those with DPB ( p\u2009&lt;\u20090.05). The EB-OCT measurement among patients with bronchiolitis and between the bronchus in the left and the right lung demonstrated a heterogeneous distribution of airway calibers, presenting a high intra- and inter-individual variability. Patients with bronchiolitis had notably greater airway wall area ( p\u2009&lt;\u20090.05) compared with control, while BO presented greater magnitude of airway abnormalities than DPB. Fres and the difference in airway resistance at 5 and 20\u2009Hz (R\n                      <jats:sub>5<\/jats:sub>\n                      \u2013R\n                      <jats:sub>20<\/jats:sub>\n                      ) correlated negatively with medium-sized and small airway inner area, and correlated positively with airway wall area ( p\u2009&lt;\u20090.05), whose correlation coefficients were higher than those of spirometric parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bronchiolitis, BO and DPB, manifested a heterogeneous distribution of airway calibers with significant intra- and inter-individual variability. IOS parameters, rather than spirometry, correlated better with medium-sized and small airway remodeling in bronchiolitis assessed by EB-OCT measurement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666231167351","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T05:54:55Z","timestamp":1681883695000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Airway morphological abnormalities of bronchiolitis assessed by endobronchial optical coherence tomography"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5583-0349","authenticated-orcid":false,"given":"Zhu-Quan","family":"Su","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Lu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangzhou First People\u2019s Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yue","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respnamiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yuan","family":"Rao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-2075","authenticated-orcid":false,"given":"Zi-Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Li","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Sate Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Sate Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"bibr1-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200212-1468OC"},{"key":"bibr2-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1620OC"},{"key":"bibr3-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106213442507"},{"key":"bibr4-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-053SO"},{"key":"bibr5-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2019.10.004"},{"key":"bibr6-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.03.008"},{"key":"bibr7-17534666231167351","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.21778.1"},{"key":"bibr8-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2000.00277.x"},{"key":"bibr9-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21080"},{"key":"bibr10-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0b013e3181809df0"},{"key":"bibr11-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.06.009"},{"key":"bibr12-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076381"},{"key":"bibr13-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1109\/42.650878"},{"key":"bibr14-17534666231167351","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S172639"},{"key":"bibr15-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00052806"},{"key":"bibr16-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.07.033"},{"key":"bibr17-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202104-0847OC"},{"key":"bibr18-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.09.006"},{"key":"bibr19-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2022.01.008"},{"key":"bibr20-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.1.63"},{"key":"bibr21-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0266-6"},{"key":"bibr22-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"bibr23-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.1.153"},{"key":"bibr24-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3289"},{"key":"bibr25-17534666231167351","doi-asserted-by":"publisher","DOI":"10.5858\/134.5.702"},{"key":"bibr26-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132015000004516"},{"key":"bibr27-17534666231167351","doi-asserted-by":"publisher","DOI":"10.4065\/81.2.172"},{"key":"bibr28-17534666231167351","first-page":"693","volume":"37","author":"Maeda M","year":"1987","journal-title":"Acta Pathol Jpn"},{"key":"bibr29-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.184.3.1509067"},{"key":"bibr30-17534666231167351","first-page":"242","volume":"52","author":"Zompatori M","year":"1997","journal-title":"Monaldi Arch Chest Dis"},{"key":"bibr31-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393662"},{"key":"bibr32-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199607000-00018"},{"key":"bibr33-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.196.1.7784583"},{"key":"bibr34-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.16.1.27"},{"key":"bibr35-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0482"},{"key":"bibr36-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198709000-00001"},{"key":"bibr37-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.4.473"},{"key":"bibr38-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.369"},{"key":"bibr39-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.05.026"},{"key":"bibr40-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.05.001"},{"key":"bibr41-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.01.010"},{"key":"bibr42-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.5_Pt_1.922"},{"key":"bibr43-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.26.7.076005"},{"key":"bibr44-17534666231167351","doi-asserted-by":"publisher","DOI":"10.1111\/all.15062"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666231167351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666231167351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666231167351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T04:39:04Z","timestamp":1740803944000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666231167351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":44,"alternative-id":["10.1177\/17534666231167351"],"URL":"https:\/\/doi.org\/10.1177\/17534666231167351","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666231167351\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231167351\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231167351\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231167351\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666231167351\/v1\/review2","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"17534666231167351"}}