{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:01:23Z","timestamp":1778799683151,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Arterial lactate is a recognized biomarker associated with death in critically ill patients. The prognostic role of arterial lactate in acute respiratory failure due to the novel coronavirus disease 2019 (COVID-19) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aimed to investigate the prognostic role of arterial lactate levels at admission in patients with COVID-19-related acute respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Methods:<\/jats:title>\n                    <jats:p>Cohorts of consecutive patients admitted to nonintensive care units (ICU) at study centers for COVID-19-related respiratory failure were merged into a collaborative database. The prognostic role of lactate levels at admission was assessed for continuous values and values \u2a7e2.0\u2009mmol\/l, and lactate clearance at 24\u2009h through delta-lactate (\u0394Lac). The study outcome was 30-day in-hospital death. Cox proportional regression model was used to assess independent predictors of the study outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At admission, 14.6% of patients had lactate levels \u2a7e2\u2009mmol\/l. In-hospital death at 30\u2009days occurred in 57 out of 206 patients; 22.3% and 56.7% with normal or \u2a7e\u20092\u2009mmol\/l lactate at admission, respectively. The median lactate level was 1.0 [interquartile range (IQR) 0.8\u20131.3] mmol\/l and 1.3 (IQR 1.0\u20132.1) mmol\/l in survivors and nonsurvivors, respectively ( p-value\u2009&lt;\u20090.001). After adjusting for age, relevant comorbidities, acidemia, and the severity of respiratory failure, lactate \u2a7e2.0\u2009mmol\/l was associated with in-hospital death (HR 2.53, 95% CI 1.29\u20134.95, p-value 0.0066), while \u0394 Lac \u2a7e0 was not (HR 1.37, 95% CI 0.42\u20134.49). These results were confirmed in patients with a pO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      -ratio (P\/F ratio) \u2a7d300\u2009mmHg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our study, increased arterial lactate at admission was independently associated with in-hospital death at 30\u2009days in non-ICU patients with acute respiratory failure related to COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666231186730","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T05:59:18Z","timestamp":1693375158000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Arterial lactate as a risk factor for death in respiratory failure related to coronavirus disease 2019: an observational study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-1297","authenticated-orcid":false,"given":"Giorgio","family":"Maraziti","sequence":"first","affiliation":[{"name":"Internal Cardiovascular and Emergency Medicine\u2013Stroke Unit, S. Maria della Misericordia Hospital, University of Perugia, Perugia 06156, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Marchini","sequence":"additional","affiliation":[{"name":"Internal Cardiovascular and Emergency Medicine\u2013Stroke Unit, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy"},{"name":"Emergency Medicine Department, Pisa University Hospital, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Falcone","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Corradi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy"},{"name":"Anaesthesia and Intensive Care Unit, Ospedali Galliera, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Graziani","sequence":"additional","affiliation":[{"name":"Internal Cardiovascular and Emergency Medicine\u2013Stroke Unit, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Ghiadoni","sequence":"additional","affiliation":[{"name":"Emergency Medicine Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Becattini","sequence":"additional","affiliation":[{"name":"Internal Cardiovascular and Emergency Medicine\u2013Stroke Unit, S. 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