{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T02:58:13Z","timestamp":1784602693615,"version":"3.55.0"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Taipei Veterans General Hospital","award":["V111B-024"],"award-info":[{"award-number":["V111B-024"]}]},{"name":"Taipei Veterans General Hospital","award":["V111C-050"],"award-info":[{"award-number":["V111C-050"]}]},{"name":"Taipei Veterans General Hospital","award":["V112B-031"],"award-info":[{"award-number":["V112B-031"]}]},{"name":"Ministry of Education, Taiwan","award":["Featured Areas Research Center Program within the"],"award-info":[{"award-number":["Featured Areas Research Center Program within the"]}]},{"name":"National Science and Technology Council","award":["MOST 109-2314-B-010-051-MY3)"],"award-info":[{"award-number":["MOST 109-2314-B-010-051-MY3)"]}]},{"name":"National Science and Technology Council","award":["NSTC 112-2314-B-075-050"],"award-info":[{"award-number":["NSTC 112-2314-B-075-050"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Coronavirus disease 2019 (COVID-19) is a global outbreak disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Cytomegalovirus (CMV) infection can occur in critical COVID-19 patients and is associated with adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to explore the clinical characteristics and outcome of CMV infection in critical COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This was a retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>From May to September 2021, SARS-CoV-2 reverse transcription polymerase chain reaction (RT\u2013PCR)-confirmed COVID-19 patients with intensive care unit (ICU) admission were enrolled. CMV infection was confirmed by PCR. Baseline characteristics, critical illness data and clinical outcomes were recorded and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seventy-two RT\u2013PCR-confirmed COVID-19 patients with ICU admission were included during the study period and 48 (66.7%) patients required mechanical ventilation (MV). Overall, in-hospital mortality was 19.4%. Twenty-one (29.2%) patients developed CMV infection. Patients with CMV infection had a higher likelihood of diabetes, higher lactate dehydrogenase and lactate levels, and higher proportions of MV, anticoagulant, and steroid use. Patients with CMV infection were associated with longer duration of SARS-CoV-2 shedding, longer ICU and hospital stay, and fewer ventilator-free days. The independent risk factor for development of CMV infection was a higher accumulative steroid dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CMV infection adversely impacted the outcomes of critical COVID-19 patients, resulting in longer ICU stays, longer mechanical ventilation uses and prolonged shedding of SARS-CoV-2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666231209150","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T22:31:51Z","timestamp":1699655511000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of the effect of cytomegalovirus infection in clinical outcomes and prolonged duration of SARS-CoV-2 shedding in intensive care unit patients with COVID-19 pneumonia"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-2937","authenticated-orcid":false,"given":"Hsiao-Chin","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei"},{"name":"Department of Medical Education, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yih","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Yen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhong-Ru","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei"},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei"},{"name":"Institute of Emergency and Critical Care Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-980X","authenticated-orcid":false,"given":"Kuang-Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Institute of Emergency and Critical Care Medicine and School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Cancer Progression Research Center, National Yang Ming Chiao Tung University, Taipei, #201, Sec. 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