{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:07:46Z","timestamp":1774382866799,"version":"3.50.1"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Key Project of the Inner Mongolia Medical University","award":["YKD2021ZD003"],"award-info":[{"award-number":["YKD2021ZD003"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The prognosis of malignant pleural effusion (MPE) is poor. A timely and accurate diagnosis is the prerequisite for managing MPE patients. Carbohydrate antigen 72-4 (CA72-4) is a diagnostic tool for MPE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to evaluate the diagnostic accuracy of pleural fluid CA72-4 for MPE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A prospective, preregistered, and double-blind diagnostic test accuracy study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We prospectively enrolled participants with undiagnosed pleural effusions from two centers in China (Hohhot and Changshu). CA72-4 concentration in pleural fluid was measured by electrochemiluminescence. Its diagnostic accuracy for MPE was evaluated by a receiver operating characteristic (ROC) curve. The net benefit of CA72-4 was determined by a decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all, 153 participants were enrolled in the Hohhot cohort, and 58 were enrolled in the Changshu cohort. In both cohorts, MPE patients had significantly higher CA72-4 levels than benign pleural effusion (BPE) patients. At a cutoff value of 8\u2009U\/mL, pleural fluid CA72-4 had a sensitivity, specificity, and area under the ROC curve (AUC) of 0.46, 1.00, and 0.79, respectively, in the Hohhot cohort. In the Changshu cohort, CA72-4 had a sensitivity, specificity, and AUC of 0.27, 0.94, and 0.86, respectively. DCA revealed the relatively high net benefit of CA72-4 determination. In patients with negative cytology, the AUC of CA72-4 was 0.67.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Pleural fluid CA72-4 helps differentiate MPE and BPE in patients with undiagnosed pleural effusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666231222333","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T06:04:04Z","timestamp":1704693844000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pleural fluid carbohydrate antigen 72-4 and malignant pleural effusion: a diagnostic test accuracy study"],"prefix":"10.1177","volume":"18","author":[{"given":"Xi-Shan","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China"},{"name":"Key Laboratory for Biomarkers, Inner Mongolia Medical University, Hohhot, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomarkers, Inner Mongolia Medical University, Hohhot, China"},{"name":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Wang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Key Laboratory, Affiliated Changshu Hospital of Nantong University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Affiliated Changshu Hospital of Nantong University, Suzhou, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-4992","authenticated-orcid":false,"given":"Zhi-De","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, China"},{"name":"Key Laboratory for Biomarkers, Inner Mongolia Medical University, Hohhot, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"bibr1-17534666231222333","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct245"},{"key":"bibr2-17534666231222333","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2013.11.007"},{"key":"bibr3-17534666231222333","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136994"},{"key":"bibr4-17534666231222333","volume":"2016","author":"Clive AO","year":"2016","journal-title":"Cochrane Database Syst 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