{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:07:12Z","timestamp":1791684432427,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Zhejiang Medical Health Science and Technology Project","award":["2024KY039"],"award-info":[{"award-number":["2024KY039"]}]},{"name":"Zhejiang Medical Health Science and Technology Project","award":["2024KY827"],"award-info":[{"award-number":["2024KY827"]}]},{"name":"Zhejiang Traditional Chinese Medicine Science and Technology Project","award":["2024ZL296"],"award-info":[{"award-number":["2024ZL296"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although high-flow nasal cannula (HFNC) oxygenation is currently recommended to prevent desaturation during sedation for bronchoscopy, there is no consensus on an optimal flow rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the optimal oxygen flow rate for HFNC to effectively prevent desaturation during sedation for bronchoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective, randomized, and controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients ( n\u2009=\u2009240) scheduled for bronchoscopy were randomized to receive HFNC with propofol sedation (fraction of inspired oxygen, 100%) at one of six flow rates of 10, 20, 30, 40, 50, and 60\u2009L\/min, designated as groups 1\u20136, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The incidence of desaturation significantly decreased by increasing the oxygen flow rate (42.5%, 17.5%, 15%, 10%, 2.5%, and 0% for groups 1\u20136, respectively, p\u2009&lt;\u20090.0001). The optimal oxygen flow rate for HFNC determined by probit regression to effectively prevent desaturation in 95% of patients was 43.20 (95% confidence interval, 36.43\u201355.96)\u2009L\/min. The requirement for airway intervention was significantly decreased by increasing the oxygen flow rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An HFNC flow rate of 50\u201360\u2009L\/min is recommended to prevent desaturation during sedation for bronchoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>NCT05298319 at ClinicalTrials.gov.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241246637","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T01:12:15Z","timestamp":1714007535000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Optimal flow of high-flow nasal cannula oxygenation to prevent desaturation during sedation for bronchoscopy: a randomized controlled study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8349-5511","authenticated-orcid":false,"given":"Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Department of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajian","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Department of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"},{"name":"Department of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangjie","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Women\u2019s Hospital, Zhejiang University School of Medicine, Xueshi Road #1, Shangcheng District, Hangzhou, Zhejiang 310006, 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