{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T08:23:49Z","timestamp":1794385429222,"version":"4.9.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The relationships between spirometric assessment of lung function and symptoms (including exacerbations) in patients with asthma and\/or chronic obstructive pulmonary disease (COPD) in a real-life setting are uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the relationships between baseline post-bronchodilator (post-BD) spirometry measures of lung function and symptoms and exacerbations in patients with a physician-assigned diagnosis of asthma and\/or COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>The NOVEL observational longiTudinal studY (NOVELTY) is a global, prospective, 3-year observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Logistic regression analysis was used to evaluate relationships. Spirometry measures were assessed as percent predicted (%pred). Symptoms were assessed at baseline, and exacerbations were assessed at baseline and Year 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 11,181 patients in NOVELTY had spirometry data (asthma, n\u2009=\u20095903; COPD, n\u2009=\u20093881; asthma + COPD, n\u2009=\u20091397). A 10% lower post-BD %pred forced expiratory volume in 1\u2009s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ) and forced vital capacity (FVC) \u2013 adjusted for age and sex \u2013 were significantly associated with dyspnea (modified Medical Research Council\u2009\u2a7e\u2009grade 2), frequent breathlessness [St George\u2019s Respiratory Questionnaire (SGRQ)], frequent wheeze attacks (SGRQ), nocturnal awakening (Respiratory Symptoms Questionnaire; \u2a7e1\u2009night\/week), and frequent productive cough (SGRQ). Lower post-BD %pred FEV\n                      <jats:sub>1<\/jats:sub>\n                      and, to a lesser extent, lower post-BD %pred FVC were significantly associated with \u2a7e1 physician-reported exacerbation at baseline or Year 1. This association was stronger in patients with COPD than in those with asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In a real-life setting, reduced lung function is consistently associated with symptoms in patients with asthma, COPD, or asthma + COPD. The relationship with exacerbations is stronger in COPD only than in asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail registration:<\/jats:title>\n                    <jats:p>clinicaltrials.gov identifier: NCT02760329 ( www.clinicaltrials.gov ).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241254212","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T04:14:05Z","timestamp":1717647245000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Relationships between symptoms and lung function in asthma and\/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6924-4500","authenticated-orcid":false,"given":"Alberto","family":"Papi","sequence":"first","affiliation":[{"name":"Respiratory Unit, Emergency Department, Research Centre on Asthma and COPD, University of Ferrara, University Hospital S. Anna, Ferrara 44124, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Hughes","sequence":"additional","affiliation":[{"name":"Research and Early Development, Respiratory and Immunology, AstraZeneca, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"del Olmo","sequence":"additional","affiliation":[{"name":"Diagnostic and Treatment Department, Hospital de Rehabilitaci\u00f3n Respiratoria \u2018Maria Ferrer\u2019 and IDIM CR, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvar","family":"Agusti","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Hospital Clinic, C\u00e1tedra de Salud Respiratoria, University of Barcelona, IDIBAPS, and CIBERES, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley E.","family":"Chipps","sequence":"additional","affiliation":[{"name":"Capital Allergy & Respiratory Disease Center, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Make","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health and University of Colorado Denver, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Tomaszewski","sequence":"additional","affiliation":[{"name":"BioPharmaceuticals Medical, Patient-Centered Science, AstraZeneca, Gaithersburg, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Peres Da Costa","sequence":"additional","affiliation":[{"name":"R&D Data Science, Real World Evidence, ZS Associates, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyansh","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Real World Evidence, ZS Associates, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Vestbo","sequence":"additional","affiliation":[{"name":"Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-R\u00e9gis","family":"Burgel","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Cochin, Assistance Publique H\u00f4pitaux de Paris"},{"name":"Institut Cochin, Inserm U1016, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-9992","authenticated-orcid":false,"given":"David","family":"Price","sequence":"additional","affiliation":[{"name":"Observational and Pragmatic Research Institute, Singapore, Singapore"},{"name":"Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"bibr1-17534666241254212","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 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