{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:00:55Z","timestamp":1777521655488,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Merck Sharp & Dohme Corp., Inc."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chronic cough (CC) affects about 10% of adults, but opioid use in CC is not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the use of opioid-containing cough suppressant (OCCS) prescriptions in patients with CC using electronic health records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Through retrospective analysis of Midwestern U.S. electronic health records, diagnoses, prescriptions, and natural language processing identified CC \u2013 at least three medical encounters with cough, with 56\u2013120\u2009days between first and last encounter \u2013 and a \u2018non-chronic cohort\u2019. Student\u2019s t-test, Pearson\u2019s chi-square, and zero-inflated Poisson models were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>About 20% of 23,210 patients with CC were prescribed OCCS; odds of an OCCS prescription were twice as great in CC. In CC, OCCS drugs were ordered in 38% with Medicaid insurance and 15% with commercial insurance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Findings identify an important role for opioids in CC, and opportunity to learn more about the drugs\u2019 effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241259373","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T01:14:57Z","timestamp":1718414097000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Prescriptions of opioid-containing drugs in patients with chronic cough"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-4583","authenticated-orcid":false,"given":"Michael","family":"Weiner","sequence":"first","affiliation":[{"name":"Indiana University Center for Health Services and Outcomes Research, Regenstrief Institute, Inc., 1101 West 10th Street, Indianapolis, IN 46202-4800, USA"},{"name":"School of Medicine, Indiana University, Indianapolis, IN, USA"},{"name":"Center for Health Information and Communication, U.S. Department of Veterans Affairs, Veterans Health Administration, Health Systems Research CIN 13-416, Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyue","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, Indiana University, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Schelfhout","sequence":"additional","affiliation":[{"name":"Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Dexter","sequence":"additional","affiliation":[{"name":"School of Medicine, Indiana University, Indianapolis, IN, USA"},{"name":"Center for Biomedical Informatics, Regenstrief Institute, Inc., Indianapolis, IN, USA"},{"name":"Eskenazi Health, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna R.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Regenstrief Data Services, Regenstrief Institute, Inc., Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Griffith","sequence":"additional","affiliation":[{"name":"Center for Biomedical Informatics, Regenstrief Institute, Inc., Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Bali","sequence":"additional","affiliation":[{"name":"Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Weaver","sequence":"additional","affiliation":[{"name":"Center for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"bibr1-17534666241259373","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.2.146"},{"key":"bibr2-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1496"},{"key":"bibr3-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.014"},{"key":"bibr4-17534666241259373","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.11-OA-0368"},{"key":"bibr5-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(06)80253-2"},{"key":"bibr6-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07115-3"},{"key":"bibr7-17534666241259373","unstructured":"McCrory DC, Coeytaux RR, Yancy WS, et al. Assessment and management of chronic cough. Report, Agency for Healthcare Research and Quality, US, January 2013."},{"key":"bibr8-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2004.07.004"},{"key":"bibr9-17534666241259373","unstructured":"Centers for Disease Control and Prevention. Provisional drug overdose death counts, https:\/\/www.cdc.gov\/nchs\/nvss\/vsrr\/drug-overdose-data.htm (2023, accessed 22 December 2023)."},{"key":"bibr10-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.0247"},{"key":"bibr11-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2019.1622013"},{"key":"bibr12-17534666241259373","volume":"8","author":"Zeiger RS","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"bibr13-17534666241259373","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/20.022"},{"key":"bibr14-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.12.011"},{"key":"bibr15-17534666241259373","unstructured":"Regenstrief Institute, Inc. nDepth, https:\/\/www.regenstrief.org\/implementation\/ndepth\/ (2019, accessed January 2024)."},{"key":"bibr16-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-892OC"},{"key":"bibr17-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-015-9628-3"},{"key":"bibr18-17534666241259373","first-page":"8","author":"Satia I","year":"2022","journal-title":"ERJ Open Res"},{"key":"bibr19-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6669.323"},{"key":"bibr20-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(87)90096-1"},{"key":"bibr21-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-020-0174-2"},{"key":"bibr22-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-019-0161-7"},{"key":"bibr23-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2021.05.004"},{"key":"bibr24-17534666241259373","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.04.007"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666241259373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666241259373","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666241259373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T17:18:51Z","timestamp":1740935931000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666241259373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":24,"alternative-id":["10.1177\/17534666241259373"],"URL":"https:\/\/doi.org\/10.1177\/17534666241259373","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666241259373\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241259373\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"17534666241259373"}}