{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:04:38Z","timestamp":1778799878041,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"the construction project of the Characteristic Backbone Discipline of Chinese medicine in Henan province, China","award":["STG-ZYX02-202108"],"award-info":[{"award-number":["STG-ZYX02-202108"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973781"],"award-info":[{"award-number":["81973781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Research on science and technology for TCM of National Administration of TCM","award":["GZY-KJS-2021-016"],"award-info":[{"award-number":["GZY-KJS-2021-016"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Some systematic reviews (SRs) on triple therapy (consisting of long-acting \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -agonist, long-acting muscarinic antagonist, and inhaled corticosteroid, LABA\/LAMA\/ICS) for chronic obstructive pulmonary disease (COPD) have reported conflicting results. As the number of syntheses increases, the task of identifying and interpreting evidence becomes increasingly complex and demanding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To provide a comprehensive overview of the efficacy and safety of triple therapy for COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Overview of SRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two independent reviewers conducted comprehensive searches in PubMed, Embase, Web of Science, and the Cochrane Library to identify relevant SRs that compared triple therapy with any non-triple therapy for COPD, from the inception of these databases until 1 June 2023. The AMSTAR 2 and GRADE tools were utilized to assess the quality of the included studies and the evidence for each outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighteen SRs encompassing 30 original studies and involving 47,340 participants were analyzed. The overall AMSTAR 2 rating revealed that 3 SRs were of low quality, 13 SRs were of critically low quality, and 2 SRs were of high quality. No high-certainty evidence revealed a significant advantage of triple therapy in improving lung function or reducing acute exacerbations. However, all evidence, including one high certainty, supported the benefits of improving quality of life. Regarding all-cause mortality, no significant difference was found when compared to LAMA or ICS\/LABA; however, high-certainty evidence confirmed its effectiveness when compared with LABA\/LAMA. Notably, high-certainty evidence indicated that triple therapy was associated with a significant increase in the risk of pneumonia compared to LABA\/LAMA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Triple therapy demonstrated notable benefits in improving lung function, reducing exacerbations, improving quality of life, and reducing all-cause mortality. However, it is important to note that it may also significantly increase the risk of pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>This overview protocol was prospectively registered with PROSPERO (No. CRD42023431548).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241259634","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T01:17:06Z","timestamp":1718414226000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative effectiveness and safety of triple therapy and non-triple therapy interventions for COPD: an overview of systematic reviews"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8627-2009","authenticated-orcid":false,"given":"Shujuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Jinshui District, Zhengzhou, Henan, People\u2019s Republic of China"},{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province & Education Ministry of P.R. 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China, Henan University of Chinese Medicine, Zhengzhou, People\u2019s Republic of China"},{"name":"Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanlin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3808-6586","authenticated-orcid":false,"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, 19 Renmin Road, Jinshui District, Zhengzhou, Henan 450046, People\u2019s Republic of China"},{"name":"Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan Province & Education Ministry of P.R. 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