{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:27:08Z","timestamp":1775579228633,"version":"3.50.1"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Chiesi Hellas S.A."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The extrafine single inhaler triple therapy (efSITT) containing beclomethasone dipropionate\/formoterol fumarate\/glycopyrronium 87\/5\/9\u2009\u03bcg has proved to be efficacious in patients with chronic obstructive pulmonary disease (COPD) in randomized control trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>TRIWIN study evaluated the effectiveness of efSITT delivering beclomethasone dipropionate\/formoterol fumarate\/glycopyrronium 87\/5\/9\u2009\u03bcg in COPD patients previously treated with multiple-inhaler triple therapy (MITT) in a real-world study in Greece.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective, multicenter, observational, non-interventional study was conducted over 24\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 475 eligible patients had moderate-to-severe COPD, an indication for treatment with efSITT, and were symptomatic despite receiving MITT. COPD Assessment Test (CAT) score, pulmonary function parameters, use of rescue medication, and adherence to inhaler use were recorded at baseline (Visit 1), 3 (Visit 2), and 6\u2009months (Visit 3) after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mean CAT score decreased from 21.4\u2009points at Visit 1, to 16.6 at Visit 2 and 15.1 at Visit 3 ( p\u2009&lt;\u20090.001 for all pair comparisons). At Visit 3, 79.8% of patients reached a CAT improvement exceeding minimal clinically important difference (\u2a7e2), compared to baseline. Mean forced expiratory volume in 1\u2009s (%pred.) increased from 55.4% at Visit 1 to 63.5% at the end of study period ( p\u2009&lt;\u20090.001), while mean forced vital capacity (%pred.) increased from 71.1% at Visit 1, to 76.7% at Visit 3 ( p\u2009&lt;\u20090.001). The mean Test of Adherence to Inhalers score increased from 42.5 to 45.3 and 46.3\u2009points, for the three visits, respectively ( p\u2009&lt;\u20090.001 comparing Visits 1\/2 and Visits 1\/3; p\u2009=\u20090.006 comparing Visits 2\/3). The percentage of patients showing good adherence rose from 33.7% at baseline to 58.3% at Visit 3. The percentage of patients using rescue medication during the last month dropped from 16.2% to 7.4% at the end of study period ( p\u2009&lt;\u20090.001). Pulmonary function parameters also improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The TRIWIN results suggest that extrafine beclomethasone dipropionate\/formoterol fumarate\/glycopyrronium is effective in improving health status, pulmonary function, and adherence and in reducing rescue medication use in COPD patients previously treated with MITT, in a real-world setting in Greece.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241263439","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:00:59Z","timestamp":1721876459000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Extrafine single inhaler triple therapy effectiveness in COPD patients previously treated with multiple-inhaler triple therapy: the TRIWIN study"],"prefix":"10.1177","volume":"18","author":[{"given":"Paschalis","family":"Steiropoulos","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Medical School, Democritus University of Thrace Medical School, University General Hospital of Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki","family":"Georgatou","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Iatriko Athinon, Palaio Faliro, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Krommidas","sequence":"additional","affiliation":[{"name":"Private Practice, Ilioupoli, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Bartziokas","sequence":"additional","affiliation":[{"name":"Private Practice, Trikala, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-9324","authenticated-orcid":false,"given":"Aliki","family":"Korkontzelou","sequence":"additional","affiliation":[{"name":"Medical, Chiesi Hellas S.A., Alimos, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panos","family":"Katerelos","sequence":"additional","affiliation":[{"name":"BioStatistics PC, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Efstathopoulos","sequence":"additional","affiliation":[{"name":"Chiesi Hellas S.A., Renou Poggi 1, Alimos, Attica 17455, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimosthenis","family":"Papapetrou","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Iatriko Athinon, Palaio Faliro, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros","family":"Theodorakis","sequence":"additional","affiliation":[{"name":"Chiesi Hellas S.A., Alimos, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Porpodis","sequence":"additional","affiliation":[{"name":"Pulmonary Department \u2013 Oncology Unit, \u2018G. 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