{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T05:52:24Z","timestamp":1793771544963,"version":"4.6.1"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Spontaneous study of the China-Japan Friendship Hospital","award":["2022-HX-85"],"award-info":[{"award-number":["2022-HX-85"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-NHLHCRF-LX-01"],"award-info":[{"award-number":["2022-NHLHCRF-LX-01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Perioperative heparin-free anticoagulation extracorporeal membrane oxygenation (ECMO) for lung transplantation is rarely reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the impact of a heparin-free strategy on bleeding and thrombotic events, blood transfusion, and coagulation function during the early perioperative period and on prognosis, and to observe its effect on different ECMO types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were collected from 324 lung transplantation patients undergoing early perioperative heparin-free ECMO between August 2017 and July 2022. Clinical data including perioperative bleeding and thrombotic events, blood product transfusion, coagulation indicators and 1-year survival were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patients were divided in venovenous (VV; n\u2009=\u2009251), venoarterial (VA; n\u2009=\u200940) and venovenous-arterial (VV-A; n\u2009=\u200933) groups. The VV group had the lowest intraoperative bleeding and thoracic drainage within 24\u2009h postoperatively. Vein thrombosis occurred in 30.2% of patients within 10\u2009days postoperatively or 1\u2009week after ECMO withdrawal, and no significant difference was found among the three groups. Double lung transplantation, increased intraoperative bleeding, and increased postoperative drainage were associated with vein thrombosis. Except for acute myocardial infarction in one patient, no other serious thrombotic events occurred. The VV-ECMO group had the lowest demand for blood transfusion. The highest prothrombin time and the lowest fibrinogen levels were observed in the VA group during ECMO run, while the highest platelet counts were found in the VV group. Both intraoperative bleeding and thoracic drainage within 24\u2009h postoperatively were independent predictors for 1-year survival, and no thrombosis-related deaths occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Short-term heparin-free anticoagulation, particularly VV-ECMO, did not result in serious thrombotic events or thrombosis-related deaths, indicating that it is a safe and feasible strategy for perioperative ECMO in lung transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241273012","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T03:29:11Z","timestamp":1724124551000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of early perioperative heparin-free anticoagulation for extracorporeal membrane oxygenation on bleeding and thrombotic events in lung transplantation: a retrospective cohort study"],"prefix":"10.1177","volume":"18","author":[{"given":"Zhijiang","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China"},{"name":"National Center for Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, China-Japan Friendship Hospital, Beijing, China"},{"name":"National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China"},{"name":"Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China"},{"name":"National Center for Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, China-Japan Friendship Hospital, Beijing, China"},{"name":"National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China"},{"name":"Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China"},{"name":"National Center for Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity, China-Japan Friendship Hospital, Beijing, 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