{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:41:39Z","timestamp":1793400099793,"version":"4.5.0"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Pliant Therapeutics, Inc."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>What is this summary about?<\/jats:p>\n                  <jats:p>This plain language summary shares results from a clinical study called INTEGRIS-IPF that was published in the American Journal of Respiratory and Critical Care Medicine in 2024. This study looked at a medicine called bexotegrast (beck-so-teh-grast) as a possible treatment for idiopathic pulmonary fibrosis (i-dee-uh-pa-thick pul-muh-ner-ee fie-bro-sis; IPF). Bexotegrast is an investigational medicine, which means that it is being studied and has not yet been approved by the US Food and Drug Administration (FDA), for people with IPF to take as a treatment. IPF is a chronic, progressive lung disease that makes it hard to breathe and gets worse over time. There is no cure for IPF, treatment includes symptom management and consideration for the use of nintedanib or pirfenidone, which may decrease the pace of disease progression.<\/jats:p>\n                  <jats:p>The study compared bexotegrast to a placebo (a treatment that looks identical to the medicine but has no medicinal effect) to look at how well it works and how safe it is in treating people with IPF. Most people in the study also took one of two medicines that are already approved by the FDA for IPF, pirfenidone or nintedanib.<\/jats:p>","DOI":"10.1177\/17534666241287307","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:00:52Z","timestamp":1731038452000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Bexotegrast in people with idiopathic pulmonary fibrosis (IPF): a plain language summary of publication of the INTEGRIS-IPF study"],"prefix":"10.1177","volume":"18","author":[{"given":"Lisa","family":"Lancaster","sequence":"first","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[{"name":"National Reference Centre for Rare Pulmonary Diseases (Orphalung), Louis Pradel Hospital, ERN-LUNG, Lyon, France"},{"name":"Claude Bernard University Lyon 1, UMR754, INRAE, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"PulmonIx, LLC at Cone Health, Greensboro, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim A.","family":"Wuyts","sequence":"additional","affiliation":[{"name":"Unit for Interstitial Lung Diseases, Department of Pneumology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Gisli","family":"Jenkins","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Scholand","sequence":"additional","affiliation":[{"name":"Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah Health, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Pneumology Departments, Mainz Lung Center, University Medical Center and Marienhaus Clinic Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"ILD Unit, Pulmonology Department, Hospital Universitario de la Princesa, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Ryerson","sequence":"additional","affiliation":[{"name":"Department of Medicine and Centre for Heart Lung Innovation, University of British Columbia, VC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Goldin","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, Los Angeles, CA, USA"},{"name":"MedQIA LLC, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Hyun J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, Los Angeles, CA, USA"},{"name":"MedQIA LLC, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Jurek","sequence":"additional","affiliation":[{"name":"Former employee of Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Decaris","sequence":"additional","affiliation":[{"name":"Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Clark","sequence":"additional","affiliation":[{"name":"Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Turner","sequence":"additional","affiliation":[{"name":"Former employee of Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris N.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardean E.","family":"Achneck","sequence":"additional","affiliation":[{"name":"Former employee of Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Cosgrove","sequence":"additional","affiliation":[{"name":"Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric A.","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Pliant Therapeutics, Inc., South San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,8]]},"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666241287307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666241287307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666241287307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T23:24:39Z","timestamp":1740957879000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666241287307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":0,"alternative-id":["10.1177\/17534666241287307"],"URL":"https:\/\/doi.org\/10.1177\/17534666241287307","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666241287307\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241287307\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241287307\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241287307\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241287307\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"17534666241287307"}}