{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:34:53Z","timestamp":1789425293825,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Health, Italy.","award":["Partially funded by the Ricerca Corrente scheme"],"award-info":[{"award-number":["Partially funded by the Ricerca Corrente scheme"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Benralizumab is a monoclonal antibody treatment for severe eosinophilic asthma (SEA). Few studies investigated its role in airway inflammation and its correlation with lung function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of the present study is to assess its effect after 1\u2009year of treatment, focusing on airway inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a retrospective observational study, in an Italian tertiary reference centre specialised in diagnosis and management of severe asthma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a monocentric retrospective study including SEA patients treated with benralizumab for 1\u2009year. Clinical, functional and inflammatory data were collected at baseline, 6 (T6) and 12 (T12) months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-two SEA patients on benralizumab were included. We observed a reduction in exacerbations rate and systemic steroid treatment ( p\u2009&lt;\u20090.0001) as well as an improvement in asthma control ( p\u2009&lt;\u20090.0001), health-related quality of life ( p\u2009=\u20090.017) and lung function pre-BD FEV1 (L) ( p\u2009=\u20090.02) and percentage ( p\u2009=\u20090.004) and post-BD FEV1 (L) ( p\u2009=\u20090.01) and percentage ( p\u2009=\u20090.003) from baseline to T6 and T12. A reduction in sputum eosinophil percentage was observed at T6 and T12 ( p\u2009&lt;\u20090.005). We found a positive correlation between the variation of sputum eosinophils percentage and FEV1 (L) at T12 (rho\u2009=\u2009\u22120.79, p\u2009=\u20090.04). Moreover, the improvement of FEF\n                      <jats:sub>25%\u201375%<\/jats:sub>\n                      from baseline to 6 (rho\u2009=\u2009\u22120.53, p\u2009=\u20090.03) and 12 (rho\u2009=\u2009\u22120.62, p\u2009=\u20090.01) months negatively correlated with the duration of asthma disease. In our cohort 12\/22 patients were super-responders at T6 and 15\/22 at T12. Furthermore, clinical remission was reached by 12\/22, and all of them obtained blood and sputum eosinophils counts normalisation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our data confirm that it is a rapid and effective treatment for SEA acting on clinical, functional, systemic and airway inflammatory outcomes. Our results highlight the role of induced sputum as a promising non-invasive technique to investigate pathophysiologic mechanisms in severe asthma treated with biologics. Finally, a negative correlation between small airway improvement and the duration of asthma may suggest that a prompt referral to asthma centres may delay lung function worsening. Additional studies are needed to investigate more in-depth the role of induced sputum in the management of asthma, response to treatment and remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241304685","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:54:26Z","timestamp":1734396866000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of benralizumab on inflammation in severe asthma: a real-life analysis"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-1623","authenticated-orcid":false,"given":"Dina","family":"Visca","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria, Varese, Italy"},{"name":"Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, via Roncaccio 16, Tradate 21049, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ardesi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zappa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Grossi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Pignatti","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3782-5021","authenticated-orcid":false,"given":"Marco","family":"Vanetti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria, Varese, Italy"},{"name":"Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pini","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Ospedali Civili, Brescia, Italy"},{"name":"Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Sotgiu","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Experimental Sciences, Clinical Epidemiology and Medical Statistics Unit, University of Sassari, Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8551-3598","authenticated-orcid":false,"given":"Rosella","family":"Centis","sequence":"additional","affiliation":[{"name":"Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Migliori","sequence":"additional","affiliation":[{"name":"Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Spanevello","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria, Varese, Italy"},{"name":"Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, 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