{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:34:51Z","timestamp":1789425291726,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"GSK","award":["Study number: 214665"],"award-info":[{"award-number":["Study number: 214665"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>REMIT is the first real-world study of mepolizumab effectiveness in patients with severe asthma (SA) in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The primary objective evaluated changes in clinically significant exacerbations (CSEs; defined as use of oral corticosteroids (OCS) or emergency department (ED) visits and\/or hospitalizations) in the 12\u2009months pre- and post-mepolizumab treatment. Secondary objectives assessed changes in the number of CSEs requiring ED visits\/hospitalizations and daily maintenance OCS (mOCS) dosage 12\u2009months pre- and post-mepolizumab treatment. Three- and four-component clinical remissions were analyzed based on OCS-free, exacerbation-free, and asthma control (\u00b1 stability in lung function).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>REMIT was a retrospective, observational, self-controlled study analyzing patients in Taiwan with SA who were newly prescribed subcutaneous mepolizumab 100\u2009mg Q4W.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data were extracted from records of 15 medical centers in Taiwan for patients indexed between November 1, 2018 and October 31, 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 170 patients were included: mean age at index date, 58.7\u2009years; 53.5% female; 100% Chinese; 7.1% with chronic rhinosinusitis with nasal polyps, 1.8% with eosinophilic granulomatosis with polyangiitis, 1.2% with hypereosinophilic syndrome; and 55.7% with blood eosinophil count &gt;300\/\u00b5L. Pre-treatment, 71.2% had \u2a7e2 exacerbations, and 28.7% were on mOCS; 75.3% had no prior biologic treatment, and 24.7% had switched from other biologics. Most patients (80.0%) completed \u2a7e10 mepolizumab doses. Following the first mepolizumab administration (index date), CSEs reduced by 46.0% (rate ratio (RR): 0.545, 95% confidence interval (CI): 0.418\u20130.710; p\u2009&lt;\u20090.0001) in the 12\u2009months post-index. Exacerbations requiring ED visits\/hospitalization reduced by 46.9% (RR: 0.531, 95% CI: 0.349\u20130.808; p\u2009=\u20090.0031). Median mOCS dose reduced by 100% by end of study and 81.8% of patients discontinued mOCS post-treatment. After 1\u2009year of mepolizumab treatment, 28% and 23% patients achieved three- and four-component clinical remission, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mepolizumab use in a patient population in Taiwan with SA significantly reduced CSEs and mOCS use in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666241308406","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T01:43:55Z","timestamp":1737337435000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["A real-world study to evaluate effectiveness of mepolizumab in treating severe asthma in Taiwan (REMIT)"],"prefix":"10.1177","volume":"19","author":[{"given":"Shih-Lung","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of 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