{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:06:28Z","timestamp":1772165188980,"version":"3.50.1"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"Summary<\/jats:title>\n \n What is this summary about?<\/jats:bold>\n <\/jats:p>\n \n \u25cf\u2003This is a plain language summary of two articles originally published in\n The New England Journal of Medicine<\/jats:italic>\n and\n The Lancet Respiratory Medicine<\/jats:italic>\n . These articles presented the results of GALATHEA and TERRANOVA, two clinical studies that took place across 41 countries.\n <\/jats:p>\n \n \u2003\u25cb\u2003GALATHEA and TERRANOVA measured how patients\u2019 COPD changed from before their first\n benralizumab<\/jats:bold>\n (10, 30, or 100\u2009mg) injection, to after 56\u2009weeks of treatment.\n <\/jats:p>\n \n \u2003\u25cb\u2003In both studies,\n benralizumab<\/jats:bold>\n was compared with\n placebo<\/jats:bold>\n .\n <\/jats:p>\n \n \u2003\u25cb\u2003To see whether\n benralizumab<\/jats:bold>\n treatment would benefit any particular patients included in these studies, researchers carried out an additional analysis following the main studies of GALATHEA and TERRANOVA.\n <\/jats:p>","DOI":"10.1177\/17534666241312060","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:52:46Z","timestamp":1741773166000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predicting response to benralizumab in patients with COPD: a plain language summary of publication of the GALATHEA and TERRANOVA studies"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-3483","authenticated-orcid":false,"given":"Gerard J.","family":"Criner","sequence":"first","affiliation":[{"name":"Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8918-7075","authenticated-orcid":false,"given":"Dave","family":"Singh","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Respiratory Medicine, University of Manchester, Medicines Evaluation Unit, Manchester University Foundation Hospitals Trust, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6924-4500","authenticated-orcid":false,"given":"Alberto","family":"Papi","sequence":"additional","affiliation":[{"name":"Respiratory Medicine, University of Ferrara, Ferrara, Italy"},{"name":"Department of Emergency Medicine, Respiratory Unit, S. Anna University Hospital, Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Jison","sequence":"additional","affiliation":[{"name":"Late Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya","family":"Makulova","sequence":"additional","affiliation":[{"name":"Late Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian H.","family":"Shih","sequence":"additional","affiliation":[{"name":"Late Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Brooks","sequence":"additional","affiliation":[{"name":"Late Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N.","family":"Barker","sequence":"additional","affiliation":[{"name":"Late Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Late Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,12]]},"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666241312060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666241312060","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666241312060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:19:13Z","timestamp":1767687553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666241312060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":0,"alternative-id":["10.1177\/17534666241312060"],"URL":"https:\/\/doi.org\/10.1177\/17534666241312060","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666241312060\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241312060\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241312060\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241312060\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241312060\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666241312060\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"17534666241312060"}}