{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:56:35Z","timestamp":1773161795576,"version":"3.50.1"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100022617","name":"Fisher and Paykel Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>High-flow nasal oxygen (HFNO) therapy delivers humidified, heated air with flow rates of up to 60\u2009L\/min with oxygen entrained. HFNO has advantages over conventional oxygen therapy, including precise and reliable fraction of inspired oxygen delivery, therefore is recommended as first-line treatment for people with acute hypoxaemic respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This pilot study aimed to determine the feasibility and acceptability of domiciliary nasal high flow (NHF) without entrained oxygen for people with chronic obstructive pulmonary disease (COPD) and severe breathlessness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Single-arm, mixed-methods, pilot study of an 8-day, air-only NHF intervention in adults with COPD and severe breathlessness not requiring domiciliary oxygen therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Participants were educated and advised to use NHF for \u2a7e7\u2009h per night for 7 nights with day use as desired. Patient-reported outcome measures were assessed on Days 3, 5 and 8. Primary outcome: feasibility. Secondary outcomes: breathlessness (dyspnoea), fatigue, quality of life, physical function, sleep, tolerability and safety. Acceptability was also assessed through semi-structured interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifteen participants were enrolled (mean age 73.6; 40% women; mean FEV\n                      <jats:sub>1<\/jats:sub>\n                      41% predicted, mean DLCO 43.0% predicted; mean modified Medical Research Council score 3.7). Thirteen (87%) completed the trial, with 8 (54%) keeping the device at the end of the trial and 3 (20%) continuing use long-term. Adherence varied, with average daily usage higher amongst participants who kept the device compared to those who returned it (6.8\u2009h\u2009\u00b1\u20092.3\u2009h vs 3.4\u2009h\u2009\u00b1\u20093.7\u2009h). No changes in worst breathlessness (mean\u2009=\u20090.7, SD\u2009=\u20091.2,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.109), dyspnoea mastery (mean\u2009=\u20090.3, SD\u2009=\u20090.6,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.176) or fatigue (mean\u2009=\u20090.0, SD\u2009=\u20092.4,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20091.00) were observed at Day 8 compared to baseline. No significant adverse events were reported. Qualitative interviews demonstrated subjective improvements in breathlessness, dry mouth and sputum production for some participants, whilst others found NHF uncomfortable. Fear of NHF dependence and concerns regarding long-term running costs were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Domiciliary NHF was a feasible intervention, albeit with varied adoption and acceptability. These trial implementation outcomes may have affected preliminary effectiveness outcomes. Further research is required to determine what role domiciliary NHF may have for people with COPD and severe breathlessness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>ACTRN12621000044820.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666251314722","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:51:28Z","timestamp":1741755088000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A mixed-methods pilot study of domiciliary nasal high-flow therapy for breathlessness in people with chronic obstructive pulmonary disease who do not qualify for domiciliary long-term oxygen therapy"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-3586","authenticated-orcid":false,"given":"Natasha","family":"Smallwood","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, Alfred Health, Prahran VIC, Australia"},{"name":"Respiratory Research@ The Alfred, School of Translational Medicine, Monash University, Level 6, Alfred Centre, 99 Commerical Rd, Prahran, VIC 3004, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3555-6856","authenticated-orcid":false,"given":"Amy","family":"Pascoe","sequence":"additional","affiliation":[{"name":"Respiratory Research@ The Alfred, School of Translational Medicine, Monash University, Prahran VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-2187","authenticated-orcid":false,"given":"Catherine","family":"Buchan","sequence":"additional","affiliation":[{"name":"Respiratory Research@ The Alfred, School of Translational Medicine, Monash University, Prahran VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron K.","family":"Wong","sequence":"additional","affiliation":[{"name":"Palliative Medicine, Peter MacCallum Cancer Centre, Parkville, VIC, Australia"},{"name":"Palliative Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-1250","authenticated-orcid":false,"given":"David","family":"Currow","sequence":"additional","affiliation":[{"name":"Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Le","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Melbourne, Parkville, VIC, Australia"},{"name":"Palliative Medicine, Peter MacCallum Cancer Centre, Parkville, VIC, Australia"},{"name":"Palliative Medicine, Royal Melbourne Hospital, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_3_4_2_2","volume-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2023 Report)","author":"Global Initiative for Chronic Obstructive Lung Disease","year":"2023","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 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