{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:47:16Z","timestamp":1785365236362,"version":"3.55.0"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The 2018 guidelines on the diagnosis of idiopathic pulmonary fibrosis (IPF) conditionally recommend multidisciplinary discussion (MDD) for diagnostic decision-making. However, limited data concerning the diagnostic impact of MDD on interstitial lung diseases (ILDs) are available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective of this prospective study was to assess the impact of MDD at a tertiary referral ILD center on diagnostic trajectories, prognosis, and identification of potential treatable traits in ILD management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This prospective study enrolled all consecutive adult ILD patients referred for MDD to a tertiary academic center in San Antonio, TX, USA from January 2017 to May 2020. The subjects were followed during a 3-year follow-up period after the MDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients were stratified into three groups according to the pre-MDD diagnosis: unspecified ILD, IPF, and not IPF, and compared to the re-stratification post-MDD diagnosis into: unclassifiable ILD, IPF, and not IPF. The primary outcome was the percentage change in diagnostic trajectories after the MDD discussion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 201 ILD patients (61.7% male; mean (DS) age: 67.2 (10.4) years) were included in the study. The total diagnostic trajectory change occurred in 122 (60.7%) patients. The diagnostic trajectories changed in 40 (46.5%) patients in the IPF group and 8 (19.5%) in the non-IPF group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -value\u2009=\u20090.0003). Patients with pre-MDD unspecified-ILD were classified as not-IPF in 32.4% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200924), IPF in 23% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200917), and unclassifiable-ILD in 44.6% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200933) post-MDD. Considering the post-MDD diagnosis, differences in mortality were detected among the three groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results suggest that MDD has a significant impact not only on the diagnostic trajectories (DT) but also on the prognosis of patients with ILDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666251323487","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T02:44:49Z","timestamp":1741920289000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic and prognostic trajectories of interstitial lung diseases after the multidisciplinary discussion"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-7785","authenticated-orcid":false,"given":"Francesco","family":"Amati","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan 20089, Italy"},{"name":"Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-3296","authenticated-orcid":false,"suffix":"III","given":"Dean L.","family":"Kellogg","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Diseases &amp; Critical Care Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA"},{"name":"Audie L. Murphy Veterans Affairs Hospital, South Texas Veterans Health Care System, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos I.","family":"Restrepo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Diseases &amp; Critical Care Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA"},{"name":"Audie L. Murphy Veterans Affairs Hospital, South Texas Veterans Health Care System, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Aliberti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"},{"name":"Respiratory Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-0433","authenticated-orcid":false,"given":"Anoop M.","family":"Nambiar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Diseases &amp; Critical Care Medicine, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA"},{"name":"Audie L. 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