{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:32:10Z","timestamp":1777984330532,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Corynebacterium jeikeium<\/jats:italic>\n                    is an uncommon but increasingly recognized cause of invasive infection, usually affecting immunocompromised patients. Empyema due to\n                    <jats:italic toggle=\"yes\">C. jeikeium<\/jats:italic>\n                    has not been previously reported in an immunocompetent adult. We describe the first case and review the existing literature on non-diphtherial\n                    <jats:italic toggle=\"yes\">Corynebacterium<\/jats:italic>\n                    -related empyema to highlight diagnostic and therapeutic challenges. A 26-year-old previously healthy man presented with 5\u2009days of pleuritic chest pain, fever, and productive cough. Chest computed tomography revealed a large, loculated left pleural effusion with an air\u2013fluid level. Initial thoracentesis yielded frank pus, confirming empyema, but the patient declined immediate drainage and was started on intravenous cefoperazone\/sulbactam and moxifloxacin. His condition worsened, prompting repeat thoracentesis and catheter drainage. Culture of pleural fluid grew\n                    <jats:italic toggle=\"yes\">C. jeikeium<\/jats:italic>\n                    , leading to a switch to intravenous vancomycin and meropenem. The patient improved rapidly, with defervescence, normalization of inflammatory markers, and complete radiographic resolution. He remained well at the 3-month follow-up. A literature review identified only four previous cases of non-diphtherial Corynebacterium-related empyema, all in patients with significant comorbidities. This case demonstrates that\n                    <jats:italic toggle=\"yes\">C. jeikeium<\/jats:italic>\n                    can cause empyema even in immunocompetent hosts. Early microbiological diagnosis, timely pleural drainage, and appropriate antimicrobial therapy, particularly vancomycin, are critical for successful outcomes. Increased awareness and case reporting will help refine management strategies for this rare but clinically relevant pathogen.\n                  <\/jats:p>","DOI":"10.1177\/17534666251412720","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:25:14Z","timestamp":1770290714000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Corynebacterium jeikeium<\/i>\n                    empyema in an immunocompetent adult: first case report and literature review"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3144-7561","authenticated-orcid":false,"given":"Khoa","family":"Nguyen-Dang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"},{"name":"Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9633-9245","authenticated-orcid":false,"given":"An","family":"Le-Hoang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-3767","authenticated-orcid":false,"given":"Quoc-Khanh","family":"Tran-Le","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"},{"name":"Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8372-2794","authenticated-orcid":false,"given":"Ngoc","family":"Duong-Minh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"},{"name":"Department of Pulmonary Medicine, Cho Ray Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-1433","authenticated-orcid":false,"given":"Hanh-Duyen","family":"Bui-Thi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.03546-2020"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1912"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.01.030"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12246"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/522996"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00542-2019"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.70230"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-214691"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2017.11.006"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000100114.54554.C1"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00796-12"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-40181-4.00131-6"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000355"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2712.210473"},{"key":"e_1_3_4_16_2","article-title":"Corynebacterium jeikeium as an Unusual Cause of Keratitis: A Case Report From a Tertiary Care Hospital in Chhattisgarh, India","volume":"13","author":"Sahu V","year":"2021","unstructured":"Sahu V, Mallika Pathak M, Das P, et al. Corynebacterium jeikeium as an Unusual Cause of Keratitis: A Case Report From a Tertiary Care Hospital in Chhattisgarh, India. Cureus 2021; 13: e20164.","journal-title":"Cureus"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00009"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01062-2022"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.337-341.2003"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.208"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.125"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9010031"},{"key":"e_1_3_4_23_2","article-title":"Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review","volume":"63","author":"Milosavljevic MN","year":"2021","unstructured":"Milosavljevic MN, Milosavljevic JZ, Kocovic AG, et al. Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review. 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